Synthesis and evaluation of [Cu]PSMA-617 targeted for prostate-specific membrane antigen in prostate cancer.

We radiolabeled a ligand, PSMA-617, of prostate-specific membrane antigen (PSMA) with copper-64 (Cu), to evaluate the metabolism, biodistribution, and potential of [Cu]PSMA-617 for PET imaging of prostate cancer. [Cu]PSMA-617 was synthesized by heating PSMA-617 with [Cu]CuCl in buffer solution at 90°C for 5 min. uptake was determined in two cell lines of prostate cancer.