Publications by authors named "Tomovic E"
N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors critical for synaptic transmission and plasticity, and for the development of neural circuits. Rare or de-novo variants in GRIN genes encoding NMDAR subunits have been associated with neurodevelopmental disorders characterized by intellectual disability, developmental delay, autism, schizophrenia, or epilepsy. In recent years, some disease-associated variants in GRIN genes have been characterized using recombinant receptors expressed in non-neuronal cells, and a few variants have also been studied in neuronal preparations or animal models.
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- Somatosensory information is transmitted to the cerebral cortex via two pathways involving VPL (ventral posterolateral) for the body and VPM (ventral posteromedial) for the head, each having unique characteristics.
- A study comparing VPL and VPM neurons in mice revealed that VPL neurons are better at firing and adapting rates compared to VPM neurons, which have shorter burst latencies and more intricate dendritic structures.
- The findings suggest significant differences in how VPL and VPM neurons handle excitatory synaptic input and intrinsic firing properties, potentially affecting their roles in processing sensory information and susceptibility to diseases.