Publications by authors named "Tomotaka Mizoguchi"
Article Synopsis
- A rare case involves a 73-year-old woman diagnosed with primary central nervous system B-cell lymphoma (PCNS-DLBCL) that presented with symptoms resembling anti-NMDAR encephalitis, as per the Graus criteria of 2016.
- Initial treatments for her acute encephalitis, including antiviral medications, were ineffective, prompting a transfer to a specialized hospital where anti-NMDAR antibodies were identified.
- After surgery to remove the tumor and subsequent therapies, her neurological symptoms improved, demonstrating a link between PCNS-DLBCL and anti-NMDAR encephalitis.
Article Synopsis
- - Acute encephalopathy, a serious brain condition linked to COVID-19, can occur weeks after recovery from the virus, as seen in a case series involving 6 patients aged 65-83 who experienced delayed symptoms.
- - These patients, who had varying severities of COVID-19 but recovered from lung issues, were hospitalized again due to confusion and neurological deficits like hemiplegia, observed 34 to 67 days post-COVID.
- - Diagnostic tests revealed elevated CSF protein levels and dysfunction of the blood-brain barrier, but no signs of active infection or neuronal autoantibodies; while some received steroid treatment, it did not improve their encephalopathy symptoms.
Neurosyphilis presenting as autoimmune limbic encephalitis: A case report and literature review.
Medicine (Baltimore)
August 2022
Rationale: Neurosyphilis presenting as limbic encephalitis (LE) is an important differential diagnosis of autoimmune LE (ALE) defined by Graus in 2016. However, data on the clinical differences and similarities between neurosyphilis presenting as LE and ALE are limited. Herein, we report neurosyphilis presenting as ALE that fulfilled the main items of the Graus ALE criteria.
View Article and Find Full Text PDFObjective: To establish the diagnostic biomarker of electroencephalogram (EEG) to distinguish between anti--methyl-d-aspartate receptor encephalitis (NMDARE) and other types of autoimmune encephalitis (other AEs).
Methods: We reviewed the clinical records of 90 patients with acute encephalitis who were treated in our institution between January 2014 and October 2020. We enrolled the patients who fulfilled the diagnostic criteria for possible AE (pAE) defined by Graus et al.
COVID-19 Post-Infectious Encephalitis Presenting With Delirium as an Initial Manifestation.
J Investig Med High Impact Case Rep
July 2021
We report the case of a 65-year-old man with COVID-19 (coronavirus disease-2019) post-infectious encephalitis who presented with delirium as an initial manifestation. He had severe COVID-19 pneumonia and recovered with dexamethasone and tocilizumab. One week after discharge, he developed abnormal behavior and delirium without fever and respiratory symptoms.
View Article and Find Full Text PDFIntramedullary spinal cord abscess (ISCA) is an extremely rare infection of the central nervous system. We report a 17-year old man with ISCA that suggested rupture confirmed by magnetic resonance imaging (MRI). The patient presented with meningeal signs, severe paraplegia, sensory impairment with a sensory level, and urinary retention.
View Article and Find Full Text PDFBackground: A unique patient with MELAS syndrome, who initially masqueraded as having acute encephalitis and was eventually diagnosed with MELAS syndrome harboring a mtDNA 14453G → A mutation, is described.
Case Presentation: A 74-year-old Japanese man was admitted to another hospital due to acute onset of cognitive impairment and psychosis. After 7 days he was transferred to our hospital with seizures and deteriorating psychosis.