Publications by authors named "Tomotaka Kumagai"
Triplet repeat diseases are caused by the abnormal elongation of repeated sequences comprising three bases. In particular, the elongation of CAG/CTG repeat sequences is thought to result in conditions such as Huntington's disease and myotonic dystrophy type 1. Although the causes of these diseases are known, fundamental treatments have not been established, and specific drugs are expected to be developed.
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- Cu-histidine-DNA hybrids were created and used as laccase-mimetic DNAzymes, demonstrating significant activity in specific oxidation reactions.
- The hybrids effectively catalyzed the oxidation of 2,4-dichlorophenol with 4-aminoantipyrine, showcasing their functional potential.
- This research contributes valuable information for designing customized active sites in biomimetic applications.
Fluorescent molecular rotors are versatile tools for the investigation of biomolecular interactions and the monitoring of microenvironmental changes in biological systems. They can transform invisible information into a fluorescence signal as a straightforward response. Their utility is synergistically amplified when they are merged with biomolecules.
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