Publications by authors named "Tomonori Wada"
Article Synopsis
- A multicenter study was conducted with 1,742 patients who achieved a sustained viral response (SVR) after chronic hepatitis C treatment to create a machine learning model for predicting the risk of developing hepatocellular carcinoma (HCC).
- Five machine learning models were evaluated, with the random survival forest (RSF) model performing the best in predicting HCC risk during a follow-up period, achieving a c-index of 0.839 in an independent cohort.
- The RSF model provides individualized risk predictions and is available online, signaling the potential to enhance surveillance strategies for HCC following SVR, although further studies are needed for tailored surveillance recommendations globally.
Background And Aims: It remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) with antiviral therapy.
Methods: In this multicenter cohort study, we enrolled patients with chronic hepatitis C who achieved SVR with interferon (IFN)-based therapy (IFN group) or direct-acting antiviral (DAA) therapy (DAA group) between January 1, 1990, and December 31, 2018. The patients underwent regular surveillance for HCC.
An 80-year old man with myelofibrosis and chronic renal disease was admitted to our hospital because of severe anemia and gastrointestinal bleeding. Although no bleeding was observed by upper or lower endoscopy, contrast-enhanced computed tomography revealed an enhanced area in the small intestinal wall that was suspected of being the bleeding site, and was confirmed by double-balloon endoscopy. Based on endoscopic findings, it was difficult to differentiate between variceal rupture and collapse of a submucosal tumor.
View Article and Find Full Text PDFBackground: Bleeding after endoscopic submucosal dissection (ESD) is a severe adverse event. Recent reports have described the efficacy of the endoscopic shielding method with polyglycolic acid (PGA) sheets and fibrin glue for the prevention of adverse events after ESD. The aim of the present study was to investigate whether the PGA shielding method provides additional benefit in preventing post-ESD bleeding compared with standard care.
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- After endoscopic submucosal dissection (ESD) for early gastric cancers, some patients end up with positive horizontal margins, but there's no established treatment plan for these cases.
- A study involving 14 hospitals examined treatments for 229 patients with positive or indeterminable margins out of nearly 12,000 ESD cases, revealing 2% had such margins.
- The findings indicated that about 68% of patients were observed without early intervention, but there’s a lack of consensus on the best treatment approach, highlighting the need for further research.
Oxaliplatin is a platinum-based chemotherapeutic agent that holds a prominent position in the treatment of colorectal and gastric cancers. However, severe oxaliplatin-related vascular pain can be problematic for patients. Here we describe seven patients who experienced severe vascular pain caused by oxaliplatin administration.
View Article and Find Full Text PDFWe herein describe a rare case of a 24-year-old man who presented with severe epigastralgia after consuming a considerable amount of broiled meat. Computed tomography revealed a cystic lesion adjacent to the distal stomach, with high intensity on T2-weighted magnetic resonance imaging. Upper endoscopy showed a cystic mass measuring 6 cm in diameter, mimicking a submucosal tumor adjacent to the pyloric valve, with duodenum invagination, characteristic of ball valve syndrome.
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