Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton.

Moesin is a member of the ezrin, radixin and moesin (ERM) proteins that are involved in the formation and/or maintenance of cortical actin organization through their cross-linking activity between actin filaments and proteins located on the plasma membranes as well as through regulation of small GTPase activities. Microglia, immune cells in the central nervous system, show dynamic reorganization of the actin cytoskeleton in their process elongation and retraction as well as phagocytosis and migration. In microglia, moesin is the predominant ERM protein.

Intracellular Cl Regulation of Ciliary Beating in Ciliated Human Nasal Epithelial Cells: Frequency and Distance of Ciliary Beating Observed by High-Speed Video Microscopy.

Small inhaled particles, which are entrapped by the mucous layer that is maintained by mucous secretion via mucin exocytosis and fluid secretion, are removed from the nasal cavity by beating cilia. The functional activities of beating cilia are assessed by their frequency and the amplitude. Nasal ciliary beating is controlled by intracellular ions (Ca, H and Cl), and is enhanced by a decreased concentration of intracellular Cl ([Cl]) in ciliated human nasal epithelial cells (cHNECs) in primary culture, which increases the ciliary beat amplitude.

Airway Ciliary Beating Affected by the Dose-Dependent [Ca] Increase in Down Syndrome Mice, Ts1Rhr.

In Ts1Rhr, a Down syndrome model mouse, the airway ciliary beatings are impaired; that is, decreases in ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of ciliary beat amplitude)). A resumption to two copies of the gene on the Ts1Rhr trisomic segment (Ts1Rhr:) rescues the decreases in CBF and CBA that occur in Ts1Rhr. In airway cilia, upon stimulation with procaterol (a β-agonist), the CBF increase is slower over the time course than the CBA increase because of cAMP degradation by Ca/calmodulin-dependent phosphodiesterase 1 (PDE1) existing in the metabolon regulating CBF.

Application of the automated haematology analyzer XN-30 in an experimental rodent model of malaria.

Background: The erythrocytic stage, where malaria parasites proliferate in human blood, is clinically significant as this causes the symptoms and illness of malaria. Experimental rodent models of malaria at the erythrocytic stage are used for the development of anti-malarial drugs and for biological analysis. An automated haematology analyzer XN-30 was developed for detection of infected red blood cells (iRBCs) in human blood samples and measurement of their parasitaemia in approximately 1 min through flow cytometry analysis.