Publications by authors named "Tomonori Kawasaki"
Dedifferentiated liposarcoma is a malignant lipomatous tumor that rarely occurs in the gastrointestinal tract, including the ileocecal region. In this case, computed tomography and magnetic resonance imaging showed no fatty mass located in the mesenteric or submucosal lesion, and positron emission tomography-computed tomography showed a high maximum standardized uptake value, collectively indicating the gastrointestinal stroma tumor and lymphoma. The pathological findings resemble leiomyosarcoma; the immunohistochemistry findings including mouse double minute 2 homolog and cyclin D-dependent kinase-4 and amplification of mouse double minute 2 homolog in fluorescence hybridization just favored the diagnosis of dedifferentiated liposarcoma with leiomyosarcoma phenotype and not leiomyosarcoma.
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- The article by Nie et al. discusses a rare case of extraskeletal osteosarcoma (EO) found in the sigmoid mesocolon, diagnosed through imaging and histopathology.
- Diagnosing EO is complicated due to non-specific imaging properties and limited immunohistochemical markers, with SATB2 being a proposed but not highly specific option.
- It's crucial to differentiate EO from other soft tissue sarcomas, like dedifferentiated liposarcoma, as some markers may overlap, complicating diagnosis.
Myofibroblastomas are benign mesenchymal tumors that frequently occur in the groin. They show variable morphology, and the differential histopathological diagnoses are broad, including lipomatous to myxoid tumors. In addition, both pathological and imaging findings may be complex, which makes diagnosis challenging.
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- ZEB1 is a crucial factor in cancer cell behavior, particularly in differentiation and metastasis, while the role of ZEB2 in head and neck squamous cell carcinoma (HNSCC) is less understood.
- In experiments with mouse oral cancer (MOC) cells, both ZEB1 and ZEB2 overexpression led to a loss of epithelial traits and promoted aggressive cell behaviors.
- Interestingly, ZEB1 overexpression was found to increase ZEB2 levels and vice versa, but ZEB2 exhibited greater potential for aggressive growth than ZEB1 in lab conditions.
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- - The case discusses a rare instance of pulmonary metastasis from renal angiomyolipoma (AML) in an 82-year-old woman, highlighting the need to differentiate between multicentric growth and true metastasis.
- - This patient had pulmonary nodules that were uniquely composed of fat, and her condition remained benign over a decade, emphasizing the atypical behavior of AML.
- - Whole-exome sequencing revealed specific mutations in the lung lesions, including a TSC2 mutation not found in her blood, suggesting that these lesions originated from her renal AML, which underscores the importance of recognizing such presentations for better diagnosis and treatment.
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Prognosis is improving with advances in multidisciplinary treatment strategies, but the development of new anticancer agents has not, and improvement in prognosis for patients with pulmonary metastases has stalled. In recent years, the tumor microenvironment (TME) has gained attention as a therapeutic target for cancer.
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- Atypical spindle cell/pleomorphic lipomatous tumor is generally classified as a benign tumor, but can be confusing to diagnose due to varying MRI findings.
- In this case, imaging suggested a potential atypical lipomatous tumor or liposarcoma, leading to a wide resection after a needle biopsy showed benign to low-grade malignancy.
- The final diagnosis was confirmed through detailed histopathology techniques, highlighting the importance of tissue analysis over imaging alone for accurate diagnosis.
IgG4-related disease is a rare fibroinflammatory disorder characterized by the infiltration of IgG4-rich plasma cells. Herein, we report a case of IgG4-related disease of the subcutaneous tissue with atypical MRI findings and difficulties in the histopathological examination using needle biopsy. Based on the clinical presentation and MRI findings, the patient was diagnosed with a benign myxoid or cystic tumor.
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- Neoadjuvant chemoimmunotherapy (NACI) is the recommended treatment for patients with operable non-small cell lung cancer (NSCLC), but finding a reliable predictor for achieving a pathological complete response (pCR) remains a challenge.* -
- A review of 50 relevant studies published between 2018 and 2022 highlighted various potential predictors for pCR, including imaging techniques like F-FDG-PET, tumor microenvironment factors, and clinical markers such as neutrophil-to-lymphocyte ratio (NLR) and smoking history.* -
- Notably, a full metabolic response on PET scans showed a 71.4% positive predictive value for pCR, while specific patterns in tumor
Primary malignant cardiac tumors rarely occur, and cardiac synovial sarcoma (SS) is especially rare among such tumors. Herein, we present the case of a 35-year-old female with primary cardiac SS treated with surgery, chemotherapy, and radiotherapy. She presented with chest symptoms and underwent imaging examinations.
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- Osteosarcoma (OS) hasn't improved much in treatment for 20 years, so researchers are looking for new ways to fight it.
- Tumor-associated macrophages (TAMs) in the tumor environment produce cytokines that can help cancer grow and spread, but their exact role in OS needs more study.
- Researchers found that a specific cytokine called IL-8, made by TAMs, boosts OS growth and spread, suggesting that targeting IL-8 could be a new way to treat this type of cancer.
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- Follicular adenomas with papillary architecture are rare thyroid tumors that are fully encapsulated and lack the cancerous nuclear traits found in papillary carcinoma.
- A case study highlights a 70-year-old woman with a painless submandibular mass; surgical analysis revealed it was a follicular adenoma with papillary architecture instead of a malignant tumor.
- The findings underscore the importance of considering follicular adenoma in the diagnosis of tumors originating from ectopic thyroid tissue.
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- The study investigates how new antirheumatic drugs affect the characteristics of lymphoproliferative disorder (LPD) in rheumatoid arthritis (RA) patients, using data from 53 hospitals in Japan between 1999 and 2021.
- A total of 752 patients with RA-associated LPD were compared to 770 with sporadic LPD, revealing notable differences in their clinical features and the impact of various drug combinations.
- The findings suggest that medications taken before LPD onset may alter its characteristics, and recommend tocilizumab (TCZ) as a better treatment option after LPD has developed.
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- The study explores the link between antinuclear antibody (ANA) levels and the effectiveness of pembrolizumab, a PD-1 blockade therapy, in treating non-small cell lung cancer (NSCLC).
- Results indicated that patients with high ANA levels had better progression-free survival (PFS) and overall survival (OS) when treated with pembrolizumab, especially those with high PD-L1 expression.
- However, no significant differences in PFS and OS based on ANA levels were observed in patients receiving a combination of chemotherapy and immunotherapy.
Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of mesenchymal origin occurring in young adults. Based on its clinical course, it is said to have an intermediate potential. We present a case of a 59-year-old woman with AFH in the hand that was difficult to diagnose.
View Article and Find Full Text PDFBackground/aim: Most cases of synovial sarcoma (SS) are aggressive and large-sized; only few show indolent behavior, having a small size. Nerves are rare sites of SS occurrence. An atypical case of SS can lead to its misdiagnosis as a benign tumor and delay its treatment.
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