15-deoxy-Δ-prostaglandin J enhances anticancer activities independently of VHL status in renal cell carcinomas.

Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Clear cell RCC (ccRCC) accounts for the majority of RCC, which have mutations or epigenetic silencing of the () gene. VHL-positive Caki-2 cells are killed by an endogenous anticancer substance, 15-deoxy-Δ-prostaglandin J (15d-PGJ).

Second-Generation Antipsychotic-Induced Hypoglycemia.

Complaints of hypoglycemia resemble the sedative effect of antipsychotics. As such, clinicians may overlook hypoglycemia in patients with psychiatric disorders. Here, a case of hypoglycemia associated with hyperinsulinemia induced by quetiapine in a female patient with bipolar disorder is reported.

Purification and characterization of phospholipase B from Candida utilis.

Phospholipase B (PLB) from the asporogenous yeast Candida utilis was purified to homogeneity from a culture broth. The apparent molecular mass was 90-110 kDa by SDS-PAGE. The enzyme had two pH optima, one acidic (pH 3.