Elucidation of the mechanism of changes in the antioxidant function with the aging in the liver of the senescence-accelerated mouse P10 (SAMP10).

Senescence-accelerated mice are known to display a variety of deficits and signs of accelerated aging, but the specific mechanisms involved in this process are still unclear. In this study, we examined the expression levels of antioxidant enzymes, transcription factors responsible for the regulation of expression of these enzymes, and mitochondrial proteins in the liver of SAMP10 and SAMR1 mice at 3 and 12 months of age using western blotting analysis. To investigate the amount of oxidative damage to DNA, levels of 8-OHdG were measured in the liver of these mice.

Maternal resveratrol intake during lactation attenuates hepatic triglyceride and fatty acid synthesis in adult male rat offspring.

Resveratrol (3,5,4-trihydroxystilbene) is a natural polyphenolic compound found in grapes and red wine and has been shown to exert protective effects on the liver preventing lipid accumulation induced by a high-fat diet. However, no studies have shown that the nutritional resveratrol intake by the parental generation has modified lipogenesis in an adult offspring. The aim of this study was to investigate whether maternal resveratrol intake during lactation affects lipogenesis in adult male rat offspring, and if it does, what is the molecular mechanistic basis.

Controlling the Molecular Direction of Dinuclear Ruthenium Complexes on HOPG Surface through Noncovalent Bonding.

We synthesized three types of binuclear Ru complexes (1-3) that contain pyrene anchors for the adsorption of 1-3 onto nanocarbon materials via noncovalent π-π interactions, in order to investigate their adsorption onto and their desorption from highly ordered pyrolytic graphite (HOPG). The adsorption saturation for 1 (6.22 pmol/cm), 2 (2.

Controlling the Direction of the Molecular Axis of Rod-Shaped Binuclear Ruthenium Complexes on Single-Walled Carbon Nanotubes.

We report the synthesis of a mixed-valence ruthenium complex, bearing pyrene moieties on one side of the ligands as anchor groups. Composites consisting of mixed-valence ruthenium complexes and SWNTs were prepared by noncovalent π-π interactions between the SWNT surface and the pyrene anchors of the Ru complex. In these composites, the long axis of the Ru complexes was aligned in parallel to the principal direction of the SWNT.