Publications by authors named "Tomomi Ishii"
Objective: The aim of this study was to assess the effect of postoperative chemotherapy on the survival of surgically treated patients with T1b uterine cervical cancer.
Methods: Overall, 1687 patients with T1b cervical cancer who received concurrent chemoradiotherapy (CCRT) or chemotherapy as postoperative adjuvant therapy were retrospectively analyzed using the Japan Society of Obstetrics and Gynecology cancer registry program data from 2015 to 2016. After propensity score matching, overall survival (OS) was compared between 643 patients treated with CCRT and 643 patients treated with chemotherapy.
Article Synopsis
- Calphostin C (Cal-C) is a known protein kinase C (PKC) inhibitor that can inhibit PKC activation at low concentrations but activate it at high concentrations through a light-dependent mechanism.
- At low doses (<200 nM), Cal-C successfully stops PKC translocation and activation induced by certain compounds, while at higher doses (>2 μM), it raises intracellular calcium levels by mobilizing the endoplasmic reticulum (ER) without involving specific receptors.
- The study also found that high concentrations of Cal-C cause structural changes in the ER and generate singlet oxygen, which contributes to PKC activation and indicates its potential use in photodynamic therapy.
Article Synopsis
- Surgery for severe endometriosis can lead to complications like injuries to the ureter, rectum, and dysfunction with urination, making careful anatomical mapping critical.
- The technique for total laparoscopic hysterectomy involves five steps: preparing the area, developing spaces to identify and isolate the ureter, and reopening the pouch of Douglas.
- Emphasizing precise anatomical landmarks during surgery helps reduce risks of complications, and each step should be consistent for safety and efficacy.
Ropivacaine is an amide local anesthetic with rare reports of anaphylaxis. To our knowledge, this is the first report of delayed nonimmune anaphylaxis induced by ropivacaine. A 70-year-old man underwent general anesthesia with a nerve block for a total knee arthroplasty.
View Article and Find Full Text PDFBackground: We investigated the effects adding opioids to epidural anesthesia on acute and chronic pain and its side effects in multimodal analgesia.
Methods: Retrospective cohort study. We retrospectively studied patients who received epidural anesthesia after thoracic surgery.
Endothelial dysfunction is associated with increased cardiovascular mortality and morbidity; however, this dysfunction may be ameliorated by several therapies. For example, it has been reported that heat-induced increases in blood flow and shear stress enhance endothelium-mediated vasodilator function. Under these backgrounds, we expect that carbon dioxide (CO)-rich water-induced increase in skin blood flow improves endothelium-mediated vasodilation with less heat stress.
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