Spatiotemporal monitoring of intracellular metabolic dynamics by resonance Raman microscopy with isotope labeling.

Cellular metabolites are valuable in a diverse range of applications. For example, the unicellular green alga produces as a secondary metabolite the carotenoid pigment astaxanthin (AXT), which is widely used in nutraceutical, cosmetic, and food industries due to its strong antioxidant activity. In order to enhance the productivity of , spatial and temporal understanding of its metabolic dynamics is essential.