Bone marrow subpopulations contain distinct types of endothelial progenitor cells and angiogenic cytokine-producing cells.

Therapeutic angiogenesis can be induced by the implantation of bone marrow cells (BMCs). However, the mechanism of BMC-mediated neovascularization remains to be clarified. We investigated the differential activities of bone marrow subpopulations in angiogenesis and cytokine production.