Publications by authors named "Tomoko Marumo"
The molecular basis of reduced autofluorescence in oral squamous cell carcinoma (OSCC) cells relative to normal cells has been speculated to be due to lower levels of free flavin adenine dinucleotide (FAD). This speculation, along with differences in the intrinsic optical properties of extracellular collagen, lies at the foundation of the design of currently-used clinical optical detection devices. Here, we report that free FAD levels may not account for differences in autofluorescence of OSCC cells, but that the differences relate to FAD as a co-factor for flavination.
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- The study investigates why oral squamous cell carcinoma (OSCC) cells exhibit reduced autofluorescence compared to normal cells, initially suggesting lower free levels of flavin adenine dinucleotide (FAD) as a cause.
- It is proposed that the autofluorescence differences are instead linked to flavination, with decreased levels of a flavoprotein, succinate dehydrogenase A (SDHA), in OSCC cells affecting their optical properties.
- Findings reveal altered metabolism in OSCC cells, indicating potential for improved diagnostic tools and targeted therapies based on these unique optical and metabolic signatures.