[Promoting Appropriate Pharmacotherapy for Home Care Patients: Coordination between Regional Comprehensive Support Centers and Pharmacies].

Japan is rapidly developing into an aged society, and its construction of a regional comprehensive care system is urgently needed for the baby boomer generation, who will reach 75 years of age in 2025. As part of providing medical care and longterm caregiving in a regional comprehensive care system, ordinary citizens will be supported in their local neighborhoods by multidisciplinary care, team medicine, and information sharing. However, pharmacists visit only once or twice per month; therefore, it can be difficult for them to grasp the overall status of patients' lifestyles.

Determination of the anticancer drug KW-2170, a pyrazoloacridone derivative, and its metabolites in human and dog plasma by high-performance liquid chromatography using an electrochemical detector.

KW-2170, 5-(3-aminopropyl) amino-7,10-dihydroxy-2-(2-hydroxethyl)-aminoethyl-6H-pyrazolo [4,5,1-de] acridin-6-one dihydroxychloride, is a novel anticancer agent under clinical development. We have established a highly sensitive method which can simultaneously quantitate KW-2170 and its two metabolites, a carboxylic (M1) and hydroxylated (M2) derivative involving the 5-position, in human and dog plasma. KW-2170 and its metabolites were extracted from plasma using a weak cation-exchange cartridge and then determined by HPLC using an electrochemical detector (ED).