Development of human Graafian follicles following transplantation of human ovarian tissue into NOD/SCID/gammac null mice.

Problem: Transplantation of human ovarian cortex into host mice may permit various kinds of challenges in reproductive medicine. A novel immunodeficient mouse strain (NOD/SCID/gammacnull: NOG) has been developed as a host of transplantation of human tissue.

Method Of Study: Human ovarian cortex was transplanted into various sites of NOG mice and human follicular development was examined by immunohistochemistry.