Publications by authors named "Tomoko Haruki"
Article Synopsis
- Artificial intelligence shows potential for diagnosing allergic conjunctival diseases (ACDs), but its development is hindered by a lack of tailored image databases and model explainability.
- This study utilized a dataset of 4,942 slit-lamp images from 10 institutions in Japan to create an AI model that diagnoses ACDs and explains its reasoning.
- Results indicated the AI model achieved a diagnostic accuracy of 86.2%, significantly outperforming board-certified ophthalmologists, and demonstrated effective identification of key clinical indicators for various ACDs.
Article Synopsis
- Atopic conditions, particularly atopic dermatitis (AD), are linked to a higher incidence and severity of HSV keratitis among patients with ocular infections.
- The study revealed that patients with AD experienced a significantly greater proliferation of HSV and a higher likelihood of recurrence compared to those without atopic conditions.
- Factors including non-infectious atopic blepharitis and asthma were particularly influential in increasing the risk of recurrent HSV keratitis.
Introduction: Dupilumab is a drug that inhibits the action of interleukin (IL)-4 and IL-13 and is a potent therapeutic drug for allergic diseases such as atopic dermatitis. Although its use has been associated with significant ocular adverse drug reactions (ADRs), the IL-4 and IL-13 inhibition may also have favorable therapeutic effects. The aim of this study was to determine the disease spectrum in which the use of dupilumab may have been associated with an increase or decrease of ocular ADRs.
View Article and Find Full Text PDFPurpose: To determine the effect of the formulation of topical medications on the healing of corneal epithelial cells after phototherapeutic keratectomy (PTK).
Study Design: Retrospective cohort study.
Methods: We studied 271 eyes of 189 consecutive patients (aged 67.
Ocular cytomegalovirus (CMV) infections in immunocompetent individuals are rare, but its activation can cause chronic and relapsing inflammation in anterior segment of the eye resulting in loss of corneal clarity and glaucoma. Fifty five patients with anterior segment CMV infection were assessed for their clinical characteristics, and CMV corneal endotheliitis was found to cause significant loss of corneal endothelial cells. The disease duration with recurrences was significantly correlated with the maximum intraocular level of CMV DNA.
View Article and Find Full Text PDFViral infections of the cornea including herpes simplex virus 1 (HSV-1) cause visual morbidity, and the corneal endothelial cell damage leads to significant visual impairment. Interferon regulatory factor 7 (IRF7) has been identified as a significant regulator in corneal endothelial cells after an HSV-1 infection. To examine the role played by IRF7, the DNA binding domain (DBD) of IRF7 of human corneal endothelial cells (HCEn) was disrupted.
View Article and Find Full Text PDFInfection of the corneal endothelial cells by human cytomegalovirus (CMV) is an important cause of corneal endotheliitis. CMV endotheliitis is difficult to completely cure and relapses are frequent. This can cause blinding corneal bullous keratopathy.
View Article and Find Full Text PDFBackground: Corneal endothelial cells are known to be targets of herpes simplex virus type 1 (HSV-1) infection; however, the pathogenesis of HSV infections of the endothelial cells has not been definitively determined. The purpose of this study was to examine an unrecognised strategy of corneal endothelial cells to protect themselves from HSV-1 infection.
Methods: Immortalised human corneal endothelial cells (HCEn) were infected with HSV-1.
Purpose: To evaluate and compare the toxic effects of moxifloxacin, cefuroxime, and levofloxacin on human corneal endothelial cells in vitro and determine the safe intracameral concentrations for them.
Setting: Tottori University, Tottori, Japan.
Design: Experimental study.
Aims: To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis.
Methods: Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined.
Purpose: To determine the transcriptional response of cultured human corneal endothelial (HCEn) cells after herpes simplex virus type (HSV-1) infection and to characterize the primary functional elements and antiviral responses.
Methods: Immortalized HCEn cells were infected with HSV-1, and the global transcriptional profile was determined. The transcriptional networks of HCEn cells were constructed, and the inflammatory network nodes were evaluated for induction of candidate inflammatory mediators by protein array analyses.
Purpose: To determine the transcriptional responses of human corneal epithelial cells (HCECs) after herpes simplex virus type (HSV)-1 infection and to identify the critical inflammatory element(s).
Method: Immortalized HCECs were infected with HSV-1, and the global transcriptional profile determined. Molecular signaling networks were constructed from the HSV-1-induced transcriptomes.