Publications by authors named "Tomoko Haneda"
Cellular xenogeneic rejection by the innate immune system is a major immunological obstruction that needs to be overcome for the successful clinical use of xenografts. Our focus has been on macrophage-mediated xenogeneic rejection, since suppressing macrophage function has considerable potential for practical applications in the area of xenotransplantation. We report herein on an investigation of the suppressive effect of human CD177 (hCD177) against macrophage-mediated xenogeneic rejection.
View Article and Find Full Text PDFBackground: Neutrophil-induced tissue damage contributes to the rejection in xenotransplantation. Therefore, suppressing neutrophil function could be effective in suppressing xenogeneic rejection. In a previous study, we demonstrated that the ectopic expression of human cluster of differentiation 31 (CD31) on porcine endothelial cells (PEC) significantly suppressed neutrophil-mediated cytotoxicity through the homophilic binding of CD31.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores how suppressing macrophage function, specifically through the T-cell immunoglobulin and ITIM domain (TIGIT), can potentially reduce xenogeneic rejection in organ transplants.
- - Researchers co-cultured naïve porcine aortic endothelial cells (PAEC) and a transfectant with TIGIT, finding that TIGIT reduced the cytotoxicity of M1 macrophages and decreased the production of pro-inflammatory cytokines like TNFα and IL-1β.
- - Overall, the study suggests that TIGIT may help protect against macrophage-induced cell damage during xenogeneic rejection, likely through mechanisms involving SHP-1 phosphorylation.