Publications by authors named "Tomoki Tanigawa"
Article Synopsis
- Researchers created a new type of hydrogelator that includes a specific molecule called benzo-15-crown-5 (B15C5).
- This hydrogelator can detect potassium ions (K), causing visible changes in the gel's appearance and color.
- The observable changes result from interactions between B15C5 and potassium, forming a unique structure known as a B15C5/K/B15C5 sandwich complex.
Article Synopsis
- A study was conducted to create and validate a prognostic index aimed at predicting 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation (DIC) who received antithrombin treatment after three days.
- The research used data from post-marketing surveys for the derivation of the index and Japan's nationwide sepsis registry for validation, identifying key risk factors such as DIC resolution and changes in Sequential Organ Failure Assessment (SOFA) scores.
- The resulting composite prognostic index (CPI) effectively classified patients, with a scoring system indicating that a CPI greater than 0.19 correlates with survival, demonstrating the tool's practicality in clinical settings.
Disseminated intravascular coagulation (DIC) is a frequent complication in patients with sepsis and is associated with increased mortality. Anticoagulant therapy may be appropriate for certain patients with DIC, particularly those with increased disease severity and deficiency in the physiologic anticoagulant antithrombin. We retrospectively analyzed post-marketing survey data from 1562 patients with sepsis-associated DIC and antithrombin activity of 70% or less.
View Article and Find Full Text PDFBackground: Disseminated intravascular coagulation (DIC) is a common and critical complication in sepsis. Antithrombin activity, which is considered a biomarker for disease severity, was measured in septic DIC treated with antithrombin concentrates in this study.
Methods: We conducted a retrospective analysis of post-marketing survey data that included 1,800 patients with sepsis-associated DIC and antithrombin activity of 70% or less who were treated with antithrombin concentrates.