Publications by authors named "Tomoki Takata"
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors.
Acta Histochem Cytochem
April 2024
Article Synopsis
- Protein lactylation, a modification linked to glycolysis, plays a role in gene regulation, but its significance in cancer, especially pancreatic tumors, is still under investigation.
- The study found increased lactylation in the nuclei of various pancreatic tumors alongside elevated levels of hypoxia-inducible factor-1α, suggesting a connection with tumor hypoxia.
- Additionally, the chemotherapy drug gemcitabine was shown to decrease histone lactylation, indicating that protein lactylation might be a factor in pancreatic cancer development and treatment.
Aim: The purpose of this study was to clarify whether fatty pancreas might lead to impaired pancreatic endocrine or exocrine function.
Material And Methods: The study involved 109 participants who had undergone the glucagon stimulation test and N-benzoyl-L-tyros-p-amino benzoic acid (BT-PABA) test to assess pancreatic function as well as unenhanced abdominal computed tomography (CT). Pancreatic endocrine impairment was defined as ΔC peptide immunoreactivity less than 2 [mmol/L] in the glucagon stimulation test, and pancreatic exocrine impairment was defined as a urinary PABA excretion rate less than 70% on the BT-PABA test.