Publications by authors named "Tomoki Sunose"
Objective: To analyze the outcomes of the underwater endoscopic ear surgery (UWEES) technique for closure of cholesteatomatous labyrinthine fistula (LF) with preservation of auditory function.
Study Design: Retrospective case review study.
Setting: Tertiary referral center.
Article Synopsis
- Enhancers and promoters help regulate RNA polymerase activity by forming stable protein complexes, known as enhanceosomes, at specific gene loci.
- Research on the mouse β-globin gene locus using the MAPit method revealed that a specific DNA element (MARE) shows high occupancy during the differentiation of certain cells, indicating strong binding of proteins in that region.
- Targeting an artificial DNA-binding domain to this MARE site reduced binding of proteins necessary for transcription, underscoring its role in recruiting transcription complexes during cell differentiation, without impacting other globin genes.