Publications by authors named "Tomoki Kai"
Introduction: Among vascular malformations, venous malformations are the most common type. Among these, retroperitoneal venous malformations are extremely rare.
Case Presentation: A 60-year-old woman was diagnosed with a retroperitoneal tumor 4.
Article Synopsis
- Mamushi bites are the most common venomous snakebites in Japan, and can lead to acute renal failure, but little is known about their effects on kidney transplant recipients.
- A case study of a 66-year-old man who was bitten by a mamushi three years post-transplant showed worsening symptoms similar to typical bites, improving after three days with proper treatment.
- The conclusion suggests that kidney transplant recipients can be managed similarly to non-recipients by maintaining immunosuppressive drugs and adequate hydration to prevent complications.
Article Synopsis
- Luteinizing hormone-releasing hormone (LHRH) antagonists might improve lower urinary tract symptoms in prostate cancer treatment compared to agonists, but their effect on acute urinary tract toxicity during radiotherapy is unclear.
- The study analyzed 78 patients receiving radiation therapy after 3-6 months of neoadjuvant therapy and evaluated urinary tract toxicity using a standardized grading scale.
- Results showed no significant reduction in urinary tract toxicity with LHRH antagonists, but patients starting with moderate to severe symptoms had significantly lower scores after treatment with antagonists compared to agonists.
Previously we reported that the microRNA miR-210 is aberrantly upregulated in clear cell renal cell carcinoma (ccRCC) via deregulation of the VHL-HIF pathway. In the present study, to investigate the biological impact of miR-210 in ccRCC tumorigenesis, we developed a transgenic mouse line expressing miR-210 in proximal tubule cells under control of the mouse SGLT2/Slc5a2 promoter. Light microscopy revealed desquamation of the tubule cells and regeneration of the proximal tubule, suggesting that miR-210 expression led to damage of the proximal tubule cells.
View Article and Find Full Text PDFThe progression from precursor lesions of pancreatic cancer, including pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm (IPMN), to invasive disease is characterized by stepwise accumulation of genetic alterations. However, it remains unclear whether additional alterations are required for the progression of high-grade neoplasms to invasive pancreatic carcinoma. We compared the genomic profiles of paired noninvasive and invasive carcinoma tissues collected from patients with IPMN.
View Article and Find Full Text PDFWe have previously reported that Salvador homologue 1 (SAV1), a component of the Hippo pathway, is significantly down-regulated in high-grade clear cell renal cell carcinoma (ccRCC) due to 14q copy number loss, and that this down-regulation contributes to the proliferation and survival of renal tubular epithelial cells through activation of Yes-associated protein 1 (YAP1), a downstream target of the Hippo pathway. However, the impact of SAV1 loss on the proliferation and survival of kidney cells in vivo remained to be determined. To address this issue, we generated kidney-specific Sav1-knockout (Cdh16-Cre;Sav1(fl/fl) ) mice.
View Article and Find Full Text PDFPreviously, we reported that genomic loss of 14q occurs more frequently in high-grade than in low-grade clear cell renal cell carcinomas (ccRCCs), and has a significant impact on the levels of expression of genes located in this region, suggesting that such genes may be involved in the malignant transformation of ccRCCs. Here, we found that six of the genes located in the minimal common region of 14q loss were significantly downregulated in high-grade ccRCCs due to copy number loss. Using a dataset from The Cancer Genome Atlas Research Network, we found that downregulation of one of these six genes, WDR20, was significantly associated with poorer outcome in patients with ccRCC, suggesting that WDR20 downregulation may be involved in the malignant transformation of ccRCCs.
View Article and Find Full Text PDFThis study was conducted to clarify the genomic profiles of metastatic clear cell renal cell carcinomas (ccRCCs) and identify the genes responsible for development of metastasis. We analyzed the genomic profiles of 20 cases of primary ccRCC and their corresponding metastases using array-based comparative genomic hybridization, and identified 32 chromosomal regions in which gene copy number alterations were detected more frequently in metastases than in the primary tumors. Among these 32 regions, 9p24.
View Article and Find Full Text PDFThree new steroidal glycosides, named solaviasides A, B, and C, have been isolated from the fruits of Solanum viarum DUNAL (syn. S. khasianum var.
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