Effects of Combination Therapy with Intravitreal Ranibizumab and Tissue Plasminogen Activator for Neovascular Age-Related Macular Degeneration.

Subretinal hyper-reflective material (SHRM) sometimes causes vision loss in spite of anti-vascular endothelial growth factor (VEGF) therapy in eyes with neovascular age-related macular degeneration (nvAMD). We evaluated the impacts of combination therapy with intravitreal ranibizumab (IVR) and tissue plasminogen activator (tPA) in eyes with nvAMD accompanying SHRM. In total, 25 eyes of 25 patients (16 men and 9 women, 76.

Selective monooxygenation of diphosphenes with molecular oxygen.

The O splitting mediated by the bulky Rind-based diphosphenes resulted in the clean formation of the mixed-valent diphosphorus compounds, diphosphene oxides, with PO moieties. Their structural features and electronic properties have been clearly characterized by experimental and theoretical methods.

A case series from a single family of familial retinal arteriolar tortuosity with common history of sudden visual loss.

Purpose: To report family members with familial retinal arteriolar tortuosity (FRAT) identified after sudden visual loss.

Observations: A 15-year-old boy had sudden visual loss in his left eye while playing on a horizontal bar. He was referred to Nagoya City University Hospital from an eye clinic.