Publications by authors named "Tomohiro Iwata"
Skeletal muscle has a high regenerative ability and maintains homeostasis by rapidly regenerating from frequent damage caused by intense exercise or trauma. In sports, skeletal muscle damage occurs frequently due to intense exercise, so practical methods to promote skeletal muscle regeneration are required. Recent studies have shown that it may be possible to promote skeletal muscle regeneration through new pathways, such as promoting autophagy and improving mitochondrial function.
View Article and Find Full Text PDFAbstract: Calorie restriction (CR) is a widely recognized dietary approach with beneficial impacts on the entire body, including enhancements in oxidative metabolism and life span extension, while maintaining nutritional balance and calorie intake. However, CR leads to reductions in skeletal muscle and fat mass due to decreased food intake. Consequently, CR significantly modifies the metabolic profile of the entire body and its tissues.
View Article and Find Full Text PDFMechanistic target of rapamycin complex 1 (mTORC1) is a protein complex that regulates skeletal muscle protein synthesis and hypertrophy. mTORC1-mediated signaling activities are activated during denervation-induced skeletal muscle atrophy and suppressed during calorie restriction-induced atrophy. Mitochondria control the qualitative plasticity of skeletal muscles primarily through biogenesis, fusion, and fission.
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- A multicenter retrospective cohort study in Japan investigated the impact of the COVID-19 pandemic on epilepsy care from January 2019 to December 2020, analyzing data such as outpatient visits, EEGs, and surgeries.
- Findings showed a decrease in outpatient visits and EEG studies and a drastic increase in telemedicine use, with significant negative effects on admissions and procedures during periods of higher COVID-19 cases and a state of emergency.
- The study highlights the substantial disruption to epilepsy care caused by the pandemic, corroborating previous research and emphasizing the extent of these changes.
Article Synopsis
- Incisional hernia is a common complication after kidney transplants, but reports on its repair are limited.
- A 55-year-old man developed an incisional hernia six months after receiving a kidney from his wife, requiring surgical repair with a special flap from the donor site.
- Post-surgery, he experienced complications like pulmonary embolism and deep vein thrombosis, which were treated successfully, and he had no recurrence of issues six months later.
Article Synopsis
- - The study tested a new treatment using a collagen-gelatin sponge infused with basic fibroblast growth factor (bFGF-CGS) for reconstructive surgery on various acute skin injuries like burns and amputations.
- - Eight male patients aged 6 to 84 underwent surgery in two stages, with effective healing observed; wound closure averaged around 32 days, with no major complications during a 6-month follow-up.
- - The results suggest that bFGF-CGS is an effective and easy-to-use regenerative tool for reconstructing severe skin defects, providing successful outcomes without the need for specialized facilities.