Publications by authors named "Tomohiko Sumi"
Article Synopsis
- A rare case of primary aldosteronism (PA) and Cushing's syndrome (CS) was reported in a 43-year-old woman, showing multiple adrenal adenomas that independently secrete cortisol and aldosterone.
- Detailed clinical and pathological investigations revealed bilateral adrenal tumors, one producing cortisol and the other producing aldosterone, confirmed by specific mRNA expressions.
- The presence of small nodules on the adrenal cortex indicated additional aldosterone production, leading to a diagnosis of one cortisol-producing adenoma, one aldosterone-producing adenoma, and adrenal hyperplasia.
We report here two interesting cases of systemic lupus erythematosus(SLE) accompanied by antiphospholipid syndrome nephropathy(APSN). These cases satisfied the criteria for SLE established by the American College of Rheumatology 1997 and also satisfied the criteria for antiphospholipid syndrome (APS) established by the Sapporo International Workshop of APS 1998. Both cases had high blood pressure with elevated plasma renin activity, proteinuria and renal dysfunction.
View Article and Find Full Text PDFThe present study was conducted to elucidate the role of oxidative stress and nuclear factor-kappaB (NF-kappaB) in the beneficial effects of angiotensin receptor blockade on obstructive nephropathy. Unilateral ureteral occlusion in rats elicited tubulo-interstitial fibrosis with concomitant macrophage infiltration and increased expression of monocyte chemoattractant protein-1. These changes were accompanied by an induction of renal cortical lipid peroxidation and activation of NF-kappaB.
View Article and Find Full Text PDFBackground: Chronic tacrolimus (FK506) nephrotoxicity is characterized by renal fibrosis with interstitial inflammation. Since nuclear factor-kappaB (NF-kappaB) plays a key role in chronic inflammatory diseases including renal disease, the present study was conducted to elucidate the role of NF-kappaB in the pathogenesis of chronic FK506-induced nephropathy.
Methods: FK506 (1 mg/kg/day, SC) was administered daily to rats maintained on low sodium diet for 42 days.