Publications by authors named "Tomohiko Ikehara"
Article Synopsis
- * The study identified a protein called SHARPIN, located on an amplified chromosome in CRC, which is overexpressed in tumor cells and linked to poor patient prognosis due to its influence on lymphatic invasion.
- * SHARPIN affects the progression of CRC by regulating the proteins MDM2 and p53, leading to changes in cell cycle and apoptosis, thus presenting SHARPIN as a potential new target for therapeutic interventions in colorectal cancer.
Background: Juvenile polyposis syndrome (JPS) is an autosomal dominant, inherited disorder characterized by multiple hyperproliferative polyps of the gastrointestinal tract, particularly of the colon, rectum, and stomach. SMAD4 mutations are frequently associated with multiple polyposis of the stomach; the condition causes severe bleeding and hypoproteinemia, which may progress to severe dysplasia and adenocarcinoma formation. We report our experience with the first case of total gastrectomy with pancreaticoduodenectomy following two partial jejunectomies for JPS, who presented with refractory anemia and protein-losing gastroenteropathy due to polyposis of the stomach and duodenum.
View Article and Find Full Text PDFBackground: Although early enteral nutrition (EEN) is an accepted practice after pancreaticoduodenectomy (PD), the impact of EEN on postoperative complications or nutritional status remains unclear. We aimed to investigate the impact of EEN on delayed gastric emptying (DGE) and nutritional status after PD.
Methods: A total of 143 patients underwent PD between January 2012 and September 2020.
Background/purpose: Postoperative pancreatic fistula (POPF) is a serious complication of pancreaticoduodenectomy and current predictors of POPF are inadequate. We developed a new fistula score to more accurately predict POPF.
Methods: We retrospectively reviewed 169 patients who underwent pancreaticoduodenectomy between January 2010 and August 2021 at our institution and examined patients' risk factors according to the occurrence of grade B/C POPF.
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are rare tumors found in the gastrointestinal tract, with about 20-30% occurring in the small intestine, often presenting with symptoms like abdominal pain and mass.
- A case involving a 69-year-old woman who experienced lower abdominal pain revealed a large pedunculated GIST that was twisted and causing hemorrhage, necessitating emergency surgery.
- This case highlights the importance of recognizing torsion of small intestine GISTs as a potential cause of acute abdomen, stressing that immediate surgical intervention is crucial to prevent complications like necrosis.
Background: It has been reported that hepatocellular carcinoma (HCC) with spindle cell tumor accounts for 1.8% of all HCCs, but spindle cell tumors that do not show an obvious conventional HCC are extremely rare. In this report, we describe a case of resection of a primary spindle cell tumor of the liver that was difficult to diagnose.
View Article and Find Full Text PDFBackground And Objectives: In today's aging society, surgery is increasingly performed for older patients with perihilar cholangiocarcinoma (PHCC). This study aimed to examine survival and oncological outcomes in octogenarians with PHCC who underwent surgery.
Methods: We retrospectively examined 480 consecutive PHCC patients treated for PHCC between 1991 and 2020.
Background: Although hepatopancreatoduodenectomy (HPD) is the only means of achieving R0 resection of widespread extrahepatic cholangiocarcinoma, its safety and oncological benefit remain controversial because of its inherent high risk of mortality and morbidity.
Objective: The aim of this study was to retrospectively analyze short- and long-term outcomes and evaluate the safety and oncological benefit of this advanced procedure.
Methods: The study cohort comprised 37 consecutive patients who had undergone major HPD.
Background: The management of positive ductal margins with carcinoma in situ (R1-CIS) after resection is controversial. The aim of this study was to evaluate the impact of R1-CIS on survival in patients who underwent resection for distal cholangiocarcinoma.
Methods: We enrolled 121 consecutive patients with distal cholangiocarcinoma.
Background: Systemic inflammation may have prognostic value in some malignancies and association with lymph node metastasis. This study aimed to evaluate the impact of systemic inflammatory biomarkers on long-term and oncological outcomes as well as to assess the association between biomarkers with lymph node metastasis in extrahepatic cholangiocarcinoma patients.
Methods: We enrolled 271 consecutive patients who underwent surgical resection for extrahepatic cholangiocarcinoma.
Background: Splenic vein stenosis and occlusion, which are known causes of left-sided portal hypertension, often occur secondary to trauma, pancreatitis, or invasion or compression by pancreatic tumors. However, few reports have described idiopathic splenic vein stenosis.
Case Presentation: A 70-year-old man was referred to our hospital for examination of isolated gastric varices.