Change in lifestyle through health promotion program without face-to-face intervention in a large-scale Japanese enterprise.

Objective: The aim of this study was to assess the effect of a health promotion program with 2-3-month Internet or printed material support without a face-to-face intervention at a large-scale worksite.

Methods: An uncontrolled intervention was conducted. In 2005, 22,429 employees underwent a health check-up and a lifestyle assessment.

Effect of melatonin on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis.

Background: The possible link between melatonin and anti-inflammatory activity is currently a focus of interest. In the present study, COX-2 expression and NF-κB activation in RAW264.7 macrophage-like cells stimulated with the fimbriae of Porphyromonas gingivalis, an oral anaerobe, in the absence and presence of melatonin were investigated.