Publications by authors named "Tomoatsu Tsuji"
Article Synopsis
- * Tests indicated acidosis and high lactic acid levels, confirming acute poisoning; the patient was treated with intravenous fluids and managed to communicate and eat by the third day.
- * Although HHCP was legal in Japan at the time, this case highlighted its potential health risks, prompting regulations in January 2024, and underscoring the need for awareness of similar incidents in the future.
Article Synopsis
- Platelet C-type lectin-like receptor 2 (CLEC-2) activates platelets when bound to its ligand, podoplanin (PDPN), which is found in inflammatory and cancer cells, increasing the risk of blood clots and tumor spread.
- Researchers discovered new compounds (diphenyl-tetrazol-propanamide derivatives) that inhibit the PDPN-CLEC-2 interaction and also block collagen-induced platelet aggregation, showcasing their potential as antiplatelet agents.
- These compounds may need modifications for clinical use, but they hold promise in treating conditions related to arterial thrombosis, venous thromboembolism (VTE), and cancer metastasis by targeting dual platelet activation pathways.
This study aimed to compare whole blood and serum concentrations of quetiapine in acute poisoning cases. Authentic whole blood and respective serum samples were routinely collected from patients diagnosed with blood poisoning at our University Hospital. Accordingly, whole blood and serum paired samples from nine patients (one male and eight female patients) were analyzed for quetiapine using liquid chromatography-mass spectrometry (LC-MS).
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- The study aims to assess the effectiveness of using grade classification for injury severity scores in the Shonan-area Medical Control Council based on injury data from 2016.
- A total of 11,668 injury cases were analyzed, revealing that most cases were mild/moderate, while a smaller number were severe or fatal; key variables were identified as significant risk factors.
- The findings suggest that incorporating Grade classification enhances the discrimination ability of severity assessments, particularly highlighting the significant influence of the "Load & Go adaptation."
Article Synopsis
- This study explored the relationship between serum potassium levels and blood caffeine concentrations in patients with acute caffeine poisoning.
- Researchers analyzed data from 85 patients who had overdosed on caffeine and found a negative correlation between potassium levels and caffeine concentration.
- They concluded that specific potassium levels (3.3 mEq/L for toxic doses and 2.9 mEq/L for lethal doses) could serve as markers for assessing caffeine toxicity.
Article Synopsis
- Podoplanin (PDPN) is a glycoprotein linked to tumor markers, platelet activation, and the process of epithelial-to-mesenchymal transition (EMT), which enhances tumor invasiveness but its exact role in these processes is not fully understood.
- In experimental methods, researchers used PDPN gene knockout and anti-PDPN antibodies on TE11A esophageal carcinoma cells to evaluate their effects on EMT-related gene expression and how they influenced cellular invasiveness and motility.
- Findings revealed that PDPN deficiency hindered cellular motility and invasiveness despite some EMT-like gene expression changes, indicating that PDPN may help maintain an epithelial state in these cancer cells.
Article Synopsis
- The study examines the health risks associated with high caffeine intake, particularly focusing on patients with acute caffeine poisoning and the difficulty of measuring their blood caffeine levels.
- Researchers analyzed data from 25 patients who overdosed on caffeine-rich tablets, assessing their clinical features and conducting urine tests for glucose and ketone bodies.
- The findings suggest a significant correlation between blood caffeine levels and the presence of glucose and ketone bodies in urine, indicating that urine tests could be useful for diagnosing and assessing the severity of acute caffeine poisoning.
Article Synopsis
- Acute urinary tract infection (UTI) is very common, and while bacterial culture tests are standard for diagnosis, they can sometimes yield false negatives, missing some pathogens.
- This study evaluated the effectiveness of next-generation DNA sequencing (NGS) in diagnosing acute UTIs by analyzing urine and blood samples from ten patients, four of whom had urosepsis.
- The results showed that NGS successfully identified bacteria in urine samples, including some that culture tests missed, and was particularly effective in detecting pathogens in patients with urosepsis, but less reliable for those without it.
This study attempted to determine the phenothiazine antipsychotics concentration in serum and whole blood samples using various diatomaceous earth-based solid-phase columns and elution solvents and subsequently evaluate their efficiency. Phenothiazine antipsychotics concentrations of 5 - 2000 ng/mL were extracted from serum and whole blood using each column. All compounds were analyzed using liquid chromatography-tandem mass spectrometry.
View Article and Find Full Text PDFCrush syndrome results in a characteristic syndrome of rhabdomyolysis with myoglobinuric acute renal failure. The most commonly described crush injury is that which affects victims of natural disasters such as earthquakes. Here, we report a rare case of crush syndrome that was induced by the kneeling seiza position.
View Article and Find Full Text PDFObjective: To investigate the immunological changes caused by severe sepsis in elderly patients.
Design: One-year, prospective observational study.
Setting: Emergency department and intensive care unit of a single university hospital.
Objective: To determine whether antithrombotic therapy with warfarin is effective and safe in patients who developed venous thromboembolism in the acute stage of polytrauma, which is associated with bleeding risk.
Method: A retrospective study of 11 patients (8 males, 3 females; mean age, 39.8 years; injury severity score, 30.
Objectives: To evaluate the use of diffusion-weighted imaging (DWI) for estimating infarcted splenic volume during partial splenic embolisation (PSE) using n-butyl cyanoacrylate (NBCA).
Methods: Twenty consecutive patients (57.2 ± 11.
A previously healthy 21-year-old woman, transported to our medical emergency center for excluding organic brain disease, had undergone medical examination 9 days before for trembling in her left hand, which was caused by stress. The patient exhibited fever and strange behaviors, e.g.
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- Performing angiography while lying on the stomach (prone position) can be tough but helpful in emergencies.
- A 60-year-old man had serious bleeding after surgery on his back and was brought to the hospital without being able to stop the bleeding.
- Doctors used a special technique called arterial embolization to fix the bleeding, and the patient recovered well and went home after 5 days.
Background: High-grade blunt renal trauma has been treated by arterial embolization (AE). However, it is unknown whether AE preserves renal function, because conventional renal function tests reflect total renal function and not the function of the injured kidney alone. Dynamic scintigraphy can assess differential renal function.
View Article and Find Full Text PDFBackground: We present a report of a blunt-trauma patient who developed an atypical extrapleural hematoma with hemodynamic instability following a dislocation fracture of the first lumbar vertebra. We successfully treated her with arterial embolization (AE) of the lumbar and intercostal arteries.
Case Report: The patient, a 74-year-old woman, was injured in a traffic accident.