Safety and Effectiveness of Elotuzumab in Japanese Patients with Relapsed/Refractory Multiple Myeloma: A Post-marketing Surveillance Study.

Objective Elotuzumab plus lenalidomide and dexamethasone (ELd) was approved in Japan in 2016 for the treatment of relapsed/refractory multiple myeloma (RRMM). This post-marketing surveillance study evaluated the safety and effectiveness of ELd in RRMM patients during routine clinical practice in Japan. Methods Elotuzumab safety was assessed by evaluating adverse drug reactions (ADRs), and effectiveness was assessed primarily by the best overall response.

Quantitative Characterization of the Affected Zones in a Single Crystal Fe-6Si Steel Sheet by Fine Piercing.

An iron loss in the motor core was often enhanced by formation of plastically affected zones in piercing the electrical steel sheets. A platform methodology to carry out quantitative evaluation of these affected zones in the pierced electrical steel sheets was proposed to search for the way to minimize the affected zone widths. A coarse-grained electrical steel sheet was employed as a work material for a fine piercing experiment under the narrowed clearance between the plasma-nitrided SKD11 punch and core-die.

Micro-/Nano-Texturing onto Plasma-Nitrided Tool Surface by Laser Printing for CNC Imprinting and Piercing.

A new data transformation method for micro-manufacturing using a topological model for a micro-/nano-texture was proposed for a surface-decorated product. Femtosecond laser printing was utilized to form the micro-/nano-textures into the hardened thick layer of dies by plasma nitriding. At first, the plasma-nitrided AISI316L flat substrate was laser-printed as a punch to imprint the tailored nano-textures onto the AA1060 aluminum plate for its surface decoration with topological emblems.

Free-Forging of Pure Titanium with High Reduction of Thickness by Plasma-Carburized SKD11 Dies.

A tool steel type SKD11 punch was plasma carburized at 673 K for 14.4 ks at 70 Pa to make carbon supersaturation. This carburized SKD11 punch was employed for upsetting the pure titanium wire with the diameter of 1.

Femtosecond Laser Trimming with Simultaneous Nanostructuring to Fine Piercing Punch to Electrical Amorphous Steel Sheets.

A CVD (Chemical Vapor Deposition) diamond coated tungsten carbide (WC) and cobalt (Co) sintered alloy punch was trimmed by the femtosecond laser machining to sharpen its edge with about 2 μm and to simultaneously make nanostructuring to its side surface. In addition to the sharpened edge, its edge profile was formed to be homogeneous enough to reduce the damage layer width by piercing the electrical amorphous steel sheet stack. Each brittle sheet in the stacked work was damaged to have three kinds of defects by piercing; e.

Dry Cold Forging of Pure Titanium Wire to Thin Plate with Use of β-SiC Coating Dies.

Dense β-SiC coating with 3C-structure was utilized as a dry cold forging punch and core-die. Pure titanium T328H wires of industrial grade II were employed as a work material. No adhesion or galling of metallic titanium was detected on the contact interface between this β-SiC die and titanium work, even after this continuous forging process, up to a reduction in thickness by 70%.

Evolution of acoustic softening effect on ultrasonic-assisted micro/meso-compression behavior and microstructure.

The application of ultrasonic vibration is an effective method to overcome the processing problems in micro/meso-forming. Previously it was observed that ultrasonic vibration could reduce flowing stress in the forming process, called ultrasonic volume effect. The volume effect contains multi-mechanisms such as stress superposition leading to apparent average stress reduction, acoustic softening and ultrasonic impact leading to real stress reductin.

Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human alpha1(III) collagen gene (COL3A1).

We have characterized the proximal promoter of the human alpha1(III) collagen gene (COL3A1). Transient transfection assays using a series of chimeric constructs linked to the luciferase gene indicated that the segment from -96 to -34 is necessary to activate transcription. Electrophoretic mobility shift assays (EMSAs) showed that the multiple proteins form the DNA-protein complex in different combinations depending on the cell types.

Preparation and characterization of chitosan microspheres containing doxifluridine.

Chitosan microspheres containing 5-fluorouracil (5-FU), tegafur (FT), and doxifluridine (DFUR) were prepared by the dry-in-oil method using silicone oil with no surfactant as a dispersion medium. For DFUR-containing chitosan microspheres (DFUR-M), reacetylation with acetic anhydride or coating using chitosan and glutaraldehyde was performed. DFUR-M, reacetylated DFUR-M, and chitosan-coated DFUR-M were investigated on in vitro drug release, and the former two microspheres were examined for in vivo degradation after subcutaneous (s.