Publications by authors named "Tomoaki Ukaji"

Aim: We aimed to determine whether baseline high-density lipoprotein (HDL) cholesterol efflux capacity (CEC) at the time of coronary angiography (CAG) could serve as a prognostic marker for future major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) through a systematic review and meta-analysis.

Methods: The MEDLINE, Cochrane, and Embase databases were used for data collection. As of April 2024, 2,871 studies have been identified.

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Article Synopsis
  • - The systematic review and meta-analysis assessed the effectiveness of paclitaxel-coated balloon angioplasty (PCB) for treating new lesions in patients with acute coronary syndrome (ACS) versus drug-eluting stents (DES).
  • - They analyzed nine studies involving over 2,000 cases, finding that the major adverse cardiac event (MACE) rates were similar between PCB (8.42%) and DES (10.62%) groups, with no significant differences in several health outcomes.
  • - The results suggest that PCB angioplasty is a feasible alternative to DES for managing de novo lesions in ACS patients during emergency procedures, with comparable midterm outcomes.
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The prognostic impact of CHADS, CHADS-VASc, and CHADS-VASc-HS scores on clinical outcomes after drug-eluting stent (DES) placement has not been fully elucidated. The present study was a retrospective, non-randomized, single-center, and lesion-based study. Target lesion failure (TLF), comprising cardiac death, non-fatal myocardial infarction, and target vessel revascularization, occurred in 7.

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Article Synopsis
  • A retrospective study was conducted to compare the effectiveness of paclitaxel-coated balloon (PCB) angioplasty versus drug-eluting stents (DESs) for treating new blockages in large coronary vessels.
  • Out of 154 patients treated, the incidence of target lesion failure (TLF) was similar between the PCB group (6.8%) and the DES group (14.6%), indicating that PCB is as effective as DESs in preventing serious cardiac events.
  • Angiographic results showed no significant cases of restenosis (re-narrowing) following PCB treatment, suggesting it may be a promising option for coronary interventions without negative outcomes.
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Article Synopsis
  • The study investigates the safety and effectiveness of drug-coated balloon (DCB) angioplasty compared to drug-eluting stents (DESs) for treating coronary stenosis, involving 588 patients treated between 2016 and 2019.
  • Overall target lesion failure (TLF) rates were similar between the DCB group (9.6%) and DES group (10.2%), indicating comparable clinical safety.
  • Additionally, the angiographic restenosis rates were not significantly different: DCB at 6.3% and DES at 10.1%, with late lumen enlargement identified as a predictor for better outcomes in DCB treatments.
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We conducted a single-center, retrospective, lesion-based study to examine the safety and efficacy of drug-coated balloons (DCBs) for de novo coronary stenosis in patients with acute coronary syndrome (ACS) by comparing them with those of drug-eluting stents (DESs).A total of 309 consecutive lesions in patients with ACS who were successfully treated by emergent procedures using either a DCB (n = 107) or a DES between January 2016 and December 2019 were included in the study. The primary endpoint was the incidence of target lesion failure (TLF), defined as cardiac death without mortality due to ACS, non-fatal myocardial infarction, and any target lesion revascularization, including acute occlusion, after DCB use and definite stent thrombosis after DES placement.

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Aim: We examined the impact of baseline high-density lipoprotein cholesterol efflux capacity (CEC) on major cardiac adverse events (MACE) in patients with coronary artery disease (CAD) during a long-term secondary prevention.

Method: CEC was measured using a cell-based efflux system in (3)[H]-cholesterol-labeled J774 macrophages in apolipoprotein B-depleted plasma between January 2011 and January 2013. Patients with CAD were divided into 2 groups as a boundary CEC value of 1: 0.

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Background: The aim of this study was to examine the reduction in the atrial conduction time during the follow-up phase of catheter ablation in persistent atrial fibrillation (PsAF) patients, which would suggest atrial reverse remodeling, and to investigate its impact on predicting AF recurrence.

Methods: Fifty-seven PsAF patients underwent radiofrequency catheter ablation. The P-wave to left atrial appendage (LAA) conduction time was measured by transthoracic echocardiography using tissue Doppler imaging (P-LAA TDI), within 24 h and 6 months after ablation.

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Background: The reduction in the left atrial appendage (LAA) flow velocity is related to the presence of emboli in atrial fibrillation (AF) patients. The LAA is located on the left superior side of the left atrial (LA) anterior wall, and we investigated the relationship between the reduction in the LAA flow velocity (LAAFV) and low voltage zones (LVZs < 0.5 mV) on the LA anterior wall.

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