Effect of N-acetylcysteine on the incidence of recurrence of otitis media with effusion and re-insertion of ventilation tubes.

Previous studies have demonstrated the anti-inflammatory, anti-oxidant, and mucolytic nature of N-acetylcysteine (NAC). Theoretically, these properties make the substance ideal for therapeutic use against otitis media with effusion (OME). The disease is characterized as a sustained non-specific inflammation of the middle ear mucosa with secretory transformation of the epithelium resulting in accumulation of fluid in the middle ear space.

[Treatment of benign paroxysmal postural vertigo in a department of otorhinolaryngology].

Benign paroxysmal positional vertigo can be succesfully treated by means of the Epley manoeuvre and vibration. This is a simple, non-invasive and economic procedure for this group of patients, who are greatly affected by vertigo in their daily life and therefore have many sick days.

[Hearing loss among premature and full-term infants in Rinköbing county. Results of tone and speech audiometry].

A material of 101 out of 111 premature infants admitted with gestational ages less than or equal to 35 weeks and birth weights less than or equal to 2,000 g to the Paediatric Department, Herning Central Hospital during the years 1977-1980 and 101 infants born at term and matched for age and sex were investigated with pure-tone audiometry in quiet surroundings and speech-audiometry in noisy surroundings in the Ringkøbing County Audiological Department in Holstebro. Where all frequencies were concerned, we found slightly more children from the premature group with hearing thresholds greater than 15 dB HL. One premature child had been equipped with a hearing aid (HA) at the age of 6 1/2 years on account of a hearing threshold in the best ear of 55 dB HL for all frequencies.

Influence of experimental rhinitis on the gonadotropin response to intranasal administration of buserelin.

The influence of experimental rhinitis on the absorption of buserelin, measured as the serum luteinizing hormone (LH) response, has been investigated. A single dose of 200 micrograms buserelin was given to 24 healthy male volunteers after induction of experimental rhinitis with histamine and after use of a saline spray (placebo control). Except on one occasion, when the pump-spray apparently was incorrectly operated, serum LH concentration rose after buserelin.

A leiomyosarcoma of the hypopharynx.

A fourth case of leiomyosarcoma of the hypopharynx is reported. The histopathological diagnosis and treatment are discussed. Surgery is still the treatment of choice and, in combination with chemotherapy (especially Methotrexate) and radiotherapy, the recurrence rate can be reduced.

Endoscopic evaluation at follow-up after Björk tracheostoma.

Fifty-six patients who had had tracheostomy of modified Björk type underwent follow-up examination with tracheal X-ray and endoscopy. In six patients the tracheal lumen was narrowed by one-fourth to one-half. No treatment was required in any case.

Profound sensorineural hearing loss in polyarteritis nodosa. An atypical case of Cogan's syndrome.

Parameters of importance for the development of thrombosis were investigated in a patient with polyarteritis nodosa (PAN) and profound sensorineural hearing loss. During the acute phase, platelet hyperaggregability, shortened platelet survival, and decreased fibrinolytic activity were found. The possibility is discussed that the etiology of the acoustico-vestibular symptoms in this patient could be an inner ear thromboembolic disorder.