Publications by authors named "Tommaso Esposito"
Tuberous sclerosis is a rare genetic disease with multiple organ involvement. Renal involvement is manifested by the presence of angiomyolipomas and cysts. Angiomyolipomas due to the progressive increase in size over time can complicate by bleeding that can lead to severe retroperitoneal hemorrhages.
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- Activation of the renin-angiotensin system (RAS) may increase renal vascular resistance (RVR) and contribute to hypertension in autosomal dominant polycystic kidney disease (ADPKD) patients.
- A study involving 34 ADPKD patients, divided into hypertensive and normotensive groups, found that plasma renin activity (PRA) was normal in both groups, but RVR was significantly higher in hypertensive patients.
- The results indicate a strong correlation between RVR and mean arterial pressure (MAP), suggesting that factors other than RAS are likely involved in early hypertension development in ADPKD patients without renal impairment.