Anti-inflammatory Effect of a Combination of Cannabidiol and Extract on Lipopolysaccharide-stimulated RAW264 Macrophages.

Background/aim: The inflammatory response plays an important role in the activation and progression of many inflammation-related diseases. Cannabis sativa and Morinda citrifolia have long been used in folk medicine to treat inflammation. Cannabidiol is the most abundant non-psychoactive phytocannabinoid in C.

Anti-Inflammatory Effects of Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells.

Leaves of (noni) have been used in Polynesian folk medicine for the treatment of pain and inflammation, and their juice is very popular worldwide as a functional food supplement. This study aimed to demonstrate that seed extract exerts anti-inflammatory effects on RAW264 cells stimulated by lipopolysaccharide. To confirm the inhibitory effect of seed extract, we assessed the production of nitric oxide (NO) and inflammatory cytokines.

Cannabidiol Content and In Vitro Biological Activities of Commercial Cannabidiol Oils and Hemp Seed Oils.

Hemp ( L.) seed contains high contents of various nutrients, including fatty acids and proteins. Cannabidiol (CBD) is a non-psychoactive compound that can be extracted from and used for treating epilepsy and pain.

Search for η^{'} Bound Nuclei in the ^{12}C(γ,p) Reaction with Simultaneous Detection of Decay Products.

We measured missing mass spectrum of the ^{12}C(γ,p) reaction for the first time in coincidence with potential decay products from η^{'} bound nuclei. We tagged an (η+p) pair associated with the η^{'}N→ηN process in a nucleus. After applying kinematical selections to reduce backgrounds, no signal events were observed in the bound-state region.

Is "Slow Inhalation" Always Suitable for Pressurized Metered Dose Inhaler?

To achieve adequate inhalation therapy, a proper inhalation technique is needed in clinical practice. However, there is limited information on proper inhalation flow patterns of commercial inhalers. Here, we quantitatively estimated airway deposition of two commercial pressurized metered dose inhalers (pMDIs) to determine their optimal inhalation patterns.

InVitro Evaluation of Optimal Inhalation Flow Patterns for Commercial Dry Powder Inhalers and Pressurized Metered Dose Inhalers With Human Inhalation Flow Pattern Simulator.

This study aimed at developing a novel analytical method to identify optimal inhalation flow patterns for commercial dry powder inhalers (DPIs) and pressurized metered dose inhalers (pMDIs). As typical commercial DPI and pMDI, Pulmicort Turbuhaler, and Sultanol Inhaler were evaluated by an in vitro inhalation performance testing system with a flow pattern simulator. An 8-stage Andersen cascade impactor (ACI) or twin stage liquid impinger (TSLI) was applied to determine the inhalation performance.

A reduced rank approach for covariance matrix estimation in EEG signal classification.

Common Spatial Pattern (CSP) methods are widely used to extract the brain activity for brain machine interfacing (BMI) based on electroencephalogram (EEG). For each mental task, CSP methods estimate a covariance matrix of EEG signals and adopt the uniform average of the sample covariance matrices over trials. However, the uniform average is sensitive to outliers caused by e.

Active data selection for motor imagery EEG classification.

Rejecting or selecting data from multiple trials of electroencephalography (EEG) recordings is crucial. We propose a sparsity-aware method to data selection from a set of multiple EEG recordings during motor-imagery tasks, aiming at brain machine interfaces (BMIs). Instead of empirical averaging over sample covariance matrices for multiple trials including low-quality data, which can lead to poor performance in BMI classification, we introduce weighted averaging with weight coefficients that can reject such trials.

Search for the Θ+ pentaquark via the π(-)p→K(-)X reaction at 1.92 GeV/c.

The Θ(+) pentaquark baryon was searched for via the π(-)p→K(-)X reaction with a missing mass resolution of 1.4 MeV/c(2) (FWHM) at the Japan Proton Accelerator Research Complex (J-PARC). π(-) meson beams were incident on the liquid hydrogen target with a beam momentum of 1.

Reaction of electron-deficient N=N, N=O double bonds, singlet oxygen, and CC triple bonds with acyloxyketenes or mesoionic 1,3-dioxolium-4-olates: generation of unstable mesoionic 1,3-dioxolium-4-olates from acyloxyketenes.

Reactions of azodicarboxylates and nitrosobenzene derivatives with acyloxyketenes generated from dehydrochlorination of alpha-acyloxyarylacetyl chlorides were carried out to give triacylbenzamidine and N-arylimide derivatives, respectively, in good yields. The same compounds were obtained from the reaction with mesoionic 1,3-dioxolium-4-olates generated by Rh2(OAc)4-catalyzed decomposition of aryldiazoacetic anhydride derivatives. Formation of the same compounds from the different starting materials indicates that their reactions involve the same intermediates.

Generation of acyloxyketenes from unstable mesoionic 1,3-dioxolium-4-olates and their reaction with ketenophiles to give [2 + 2] cycloadducts.

Fast ring opening of mesoionic 1,3-dioxolium-4-olates, generated by Rh(2)(OAc)(4)-catalyzed decomposition of phenyldiazoacetic anhydride derivatives, to acyloxyphenylketenes was demonstrated by trapping the ketenes with several ketenophiles. Reactions of phenyldiazoacetic anhydride derivatives with several ketenophiles such as dihydrofuran, carbodiimides, and imines were carried out. No 1,3-dipolar cycloadducts of the latter with 1,3-dioxolium-4-olates were observed.

Unique characteristics of two types of retinitis pigmentosa patients with different rod sensitivities.

Purpose: To determine the psychophysical differences between two types of retinitis pigmentosa (RP) patients with different rod sensitivities.

Methods: Thirty-five RP patients with a visual acuity of > or =0.7 or better were classified by cone-rod perimetry into type 1, those with undetectable rod sensitivity, and type 2, those with measurable rod sensitivity.

[Suppressive rod-cone interaction in complete and incomplete congenital stationary night blindness].

Dark-adapted rods have a suppressive effect on cone response (suppressive rod-cone interaction: SRCI). This phenomenon has been applied to analyze the pathological mechanism of congenital stationary night blindness (CSNB), but the results have been discrepant among the investigators. Alexander et al reported that 2 individuals with CSNB exhibited a normal SRCI, but Arden and Hogg reported an absence of SRCI in 4 cases of CSNB.