Publications by authors named "Tomer Bar-Noy"
Article Synopsis
- The IGF system is crucial in regulating growth and invasiveness in epithelial ovarian cancer (EOC) and is considered a potential target for therapy, although its role in the immune response within the EOC microenvironment is not well understood.
- The study tested the hypothesis that inhibiting the IGF1 receptor (IGF1R) alongside PD-1 would impact dendritic cell maturation and the EOC environment.
- Results showed that the combined treatment reduced tumor weight and increased immune responses, suggesting that targeting IGF1R and PD-1 together could be an effective strategy for treating certain EOC patients.
Background: Misoprostol treatment for early pregnancy loss has varied success demonstrated in previous studies. Incorporating predictors in a single clinical scoring system would be highly beneficial in clinical practice.
Objective: To develop and evaluate the accuracy of a scoring system to predict misoprostol treatment outcomes for managing early pregnancy loss.
Objective: We aimed to study the association between obesity and survival in ovarian cancer (OC) patients, accounting for confounders as disease stage, histology, and comorbidities.
Methods: Retrospective matched case-control study of consecutive patients, with epithelial OC. Obese (body mass index [BMI] ≥ 35 kg m) patients were matched in a 1:4 ratio with patients having lower BMIs (BMI < 35 kg m) based on disease stage, cytoreduction state, tumor histology and ASA score.
Factors Affecting the Success of Repeated Misoprostol Course for the Treatment of Missed Abortion.
J Gynecol Obstet Hum Reprod
December 2022
Objective: To assess the rates of success of the second dose of Misoprostol administration and to evaluate the parameters that affect the success of this approach.
Study Design: This retrospective cohort study was performed using institutional database of Carmel Medical Center between the dates of 1/11/2012-1/11/2017. Patients with ultrasound proven intrauterine abnormal pregnancy, treated for missed abortion or blighted ovum by two doses of intravaginal Misoprostol were included.
Objective: To study the possible association between uterine cancer and the BRCA1/2 associated cancer syndrome and discuss the implications of such an association on the clinical managment of patients with BRCA1/2 mutations.
Methods: A systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. Study protocol was prospectively registered at PROSPERO International prospective register of systematic reviews (registration number CRD42020193496).
Background: Male infertility is solely responsible for approximately 20% of all infertility in couples. Various factors have been proposed as having a negative effect on sperm quality; however, the reasons for the global decline in sperm parameters during the last few decades are still controversial.
Objectives: To investigate the fluctuations of semen parameters (sperm concentration, motility, and morphology) in three sperm quality groups and to examine the trends of those parameters in the same men over time.