Publications by authors named "Tomaz Krumpestar"
Article Synopsis
- Hypoxia in lung cancer negatively impacts prognosis, and this study focuses on the role of prolyl hydroxylase domain proteins (PHDs) in oxygen sensing and their correlation with the hypoxia-inducible factor (HIF) pathway in non-small-cell lung cancer (NSCLC).
- Researchers analyzed tumor tissues from 60 NSCLC patients using RT-qPCR to measure mRNA expression levels of specific genes and compared them to normal lung tissues, finding significant reductions in tumor samples.
- Results indicated that lower levels of certain mRNAs were linked to larger tumor sizes, advanced cancer stages, and shorter overall survival, suggesting these mRNAs could serve as potential prognostic markers in NSCLC.
Asthma is a common chronic disease, with different underlying inflammatory mechanisms. Identification of asthma endotypes, which reflect a variable response to different treatments, is important for more precise asthma management. T2 asthma is characterized by airway inflammation driven by T2 cytokines including interleukins IL-4, IL-5, and IL-13.
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