Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats.

Zinc is an endogenous modulator of neuronal activity and may play an important role in the pathogenesis of depression. Recent studies have shown that zinc exhibits antidepressant-like activity in some models of depression in rodents. Our previous studies have shown that the footshock-induced fighting behavior was reduced in the rats subjected to chronic unpredictable stress (CUS).

[Pulmonary complications in patient with ulcerative colitis, treated with 5-aminosalicylic preparations].

Pulmonary complications in patients with ulcerative colitis treated with 5-aminosalicylic acid are infrequent adverse events. The authors present a 35-year-old man, taking sulfasalazine and mesalazine in whom pulmonary abnormalities resembling tuberculosis were observed during several months of therapy. Withdrawal of mesalazine resulted in complete resolution of lung injury.

Influence of dizocilpine (MK-801) on neurotoxic effect of dexamethasone: behavioral and histological studies.

Elevated levels of endogenous glucocorticoids (GCs) or prolonged treatment with high doses of dexamethasone (DEX) or other GCs preparations are frequently associated with psychosis as well as cognitive deficits, such as the impairment of memory and learning. GCs potentiate stress or ischemia-induced accumulation of excitatory amino acids in the extracellular space of hippocampus. The antagonism of glutamate receptors may potentially improve safety profile of therapy with GCs.

Effect of NMDA receptor antagonists on behavioral impairment induced by chronic treatment with dexamethasone.

Severe and prolonged stress but also long-term treatment with glucocorticoids (GCs) have been described to cause brain damage (especially hippocampal and striatal neurons) in humans as well as in animals. GCs potentiate stress or ischemia-induced accumulation of excitatory amino acids (EAA) in the extracellular space of the hippocampus. It was shown that EAA play a major role in various neurologic disorders with cognitive dysfunction.

Evaluation of the effectiveness of short-term smoking cessation treatment in patients of the Pulmonary Department, Medical University of Lublin.

From August to December 2001 antinicotine program was performed in the Pulmonary Department of the Medical University of Lublin in order to achieve smoking cessation of hospitalized patients, their families and other people coming to the ambulatory during the "open door" days. The usefulness of the smoker's registration in a specialist ambulatory and effectiveness of specialist advice was analyzed. Three hundred ninety persons were examined and given advice.