[Chemoprevention of colorectal cancer].

Gastrointestinal cancer poses a major clinical challenge in the developed world where the disease is common. Cancer chemoprevention is defined as the use of natural, synthetic or chemical agents to reverse, suppress or prevent carcinogenic progression to invasive cancer. The success of several clinical trials in preventing cancer in high-risk populations suggests that chemoprevention can be rational strategy.

[Perspectives in inflammatory bowel diseases treatment].

Development in immunology and better understanding of prolonged inflammatory process is basic in inflammatory bowel diseases treatment development. The new generation of drugs could be included infliximab and adalimumab. To the same group we include tumour necrosis factor inhibitors (infliximab, adalimumab, etanercept, certolizumab, onercept), selective adhesive molecules inhibitors (natalizumab, alicaforsen), Th1 dependent reaction inhibitors (anti-il-12, tacrolismus, il-10), lymphocytes migration inhibitors (natalizumab).

[Dehydroepiandrosterone (DHEA)--slows down the aging process?].

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are secondary adrenal androgens, mainly produced in the reticular layer as well as in the gonads and in the central nervous system. These prohormones influence many functions in human organism, but their most important effect seems to slow down the ageing process. It is well known that the concentrations of both substances are decreasing substantially with age, beginning at 50.