Thromboprophylaxis in hospitalized COVID-19 patients: the efficacy and safety of the approved hospital protocol.

Introduction: Prothrombotic coagulopathy in COVID-19 has led to a strong recommendation for thromboprophylaxis in all hospitalized patients, although there are large differences in the dosage regimens among hospitals and their outcomes remain uncertain. Objectives: We aimed to determine the incidence of thrombotic events and bleeding in patients with COVID-19 using the approved local thromboprophylaxis protocol. Patients and methods: We adapted a self-developed pharmacological thromboprophylaxis protocol based on clinical and laboratory risk assessment of thrombosis in 350 consecutive patients (median age, 67 years) with confirmed COVID-19, treated in designated wards at a single center in Kraków, Poland from October 10, 2020, to April 30, 2021.

Coronaviruses fusion with the membrane and entry to the host cell.

Coronaviruses (CoVs) are positive-strand RNA viruses with the largest genome among all RNA viruses. They are able to infect many host, such as mammals or birds. Whereas CoVs were identified 1930s, they became known again in 2003 as the agents of the Severe Acute Respiratory Syndrome (SARS).

Increased levels of interleukin 27 in patients with early clinical stages of non-small cell lung cancer.

INTRODUCTION    Interleukin 27 (IL‑27) is a cytokine secreted mostly by antigen‑presenting cells. It is important for the immune polarization of T helper‑1 (Th1) cells, and its role in interstitial lung diseases (ILDs) and lung cancer has been investigated. OBJECTIVES    We assessed IL‑27 expression in the lower airways of patients with selected ILDs and early‑stage non-small cell lung cancer (NSCLC).

Fulminant heart failure due to giant cell myocarditis affecting the left ventricle.

A 56-year-old woman, previously healthy, was hospitalized after an episode of ventricular tachycardia in the course of infection. In view of the fulminant course of heart failure the patient was connected to an extracorporeal membrane oxygenation (ECMO) system. After 3 weeks of treatment with ECMO the patient received a heart transplant.

[The effectiveness of RF ablation of ventricular ectopic beats made using selected mapping techniques].

Unlabelled: Only several world-leading centers have summarized outcomes of invasive therapy of ventricular arrhythmia.

Aim: The aim of the work is to compare the effectiveness of RF ablation of ventricular arrhythmia.

Materials And Methods: 183 patients (111 males, mean age 50 ± 17) underwent RF ablation of ventricular ecopic beats (VEB).

[Factors predisposing to the reprogramming of implantable cardioverter-defibrillators and the causes of changes in pharmacotherapy in patients with dilated cardiomyopathy for primary prevention of sudden cardiac death].

Unlabelled: Ambulatory care of patients with implantable cardioverter-defibrillator (ICD) involves regular follow-up visit, where a decision on reprogramming of the device and modification of pharmacotherapy is made.

Aim: The aim of the study was the assessment of frequency and reasons of reprogramming and pharmacotherapy changes in patients with dilated cardiomyopathy with an ICD implanted due to primary prevention of sudden cardiac death (SCD).

Materials And Methods: The study included 143 consecutive patients with an ICD implanted in 2010-2011.

[Electrocardiologic opportunities for the treatment of recurrent ventricular tachycardia on the example of a patient with arrhythmogenic right ventricular dysplasia].

Arrhythmogenic right ventricular dysplasia is a genetic disease, in which pathologic fibrofatty tissue occurs mainly in the right ventricle of the heart. Changes in heart muscle predispose to arrhythmias such as ventricular tachycardia or ventricular fibrillation, so these patients are candidates for implantation of implantable cardioverter-defibrillator. Furthermore, depending on the indication, RF-ablation is performed, which, due to changes in morphology of the heart muscle, are often difficult and of uncertain efficacy.

[Quality of life in patients after anti-arrhythmic devices implantation].

The Aim Of Study: To assess changes in quality of life in patients with advanced heart failure before ICD or CRTD implantation and after 6 months follow-up period.

Material And Methods: The quality of life study was performed in group consisting of 98 patients (69 male, mean age 70.4 +/- 8.

Determinants of patient survival rate after implantation of a cardioverter-defibrillator without resynchronisation capability.

Background: Proper selection of patients at high risk for sudden cardiac death (SCD) and increasing use of implantable cardioverter-defibrillators (ICD) may contribute to improved survival among patients at the highest SCD risk.

Aim: To assess patient survival rate after implantation of an ICD without resynchronisation capability in our own patient population. Using uni- and multivariate analysis, we attempted to identify factors associated with significant worsening of patient survival rate.

[Effectiveness of RF ablation of ventricular ectopic beats from the right and (or) left ventricle].

Unlabelled: There are few studies on the immediate and long term efficacy of ablation of ventricular ectopic beat (VEB) using different mapping systems arrhythmia. The aim of the study was to evaluate the efficacy of intraoperative, immediate and late outcome of RF ablation ventricular arrhythmias and a comparison of methods for identification and ablation of arrhythmia substrate.

Material And Methods: In 88 patients, average age 50,8+/-17,8 years old (16 to 90) with performed RF ablation of VEB from the left ventricular and (or) right ventricular.

[Evaluation of the early effectiveness and late arrhythmia recurrences subjectively experienced by the patient after RF ablation of accessory pathway in Wolf-Parkinson-White syndrome depending on it's localization and the electrical parameters of ablation--own observation].

Unlabelled: Nowadays, radiofrequency ablation (RF) is recommended treatment method of atrioventricular reentrant tachycardia associated with accessory pathway. This procedure is characterised by high early and late efficacy and low risk of complication. The aim of this study was to evaluate early effectiveness and late arrhythmia recurrences subjectively experienced by the patient after RF ablation of accessory pathway in Wolf-Parkinson-White Syndrome, depending on it's localization and the electrical parameters of ablation.