Publications by authors named "Tomasz Rywik"
Background/objectives: The pathophysiological background of the processes activated by physical activity in patients with heart failure (HF) is not fully understood. Proteomic studies can help to preliminarily identify new protein markers for unknown or poorly defined physiological processes. We aimed to analyse the changes in the plasma proteomic profile of HF patients after a cardiopulmonary exercise test (CPET) to define pathways involved in the response to exercise.
View Article and Find Full Text PDFIntroduction: Recently, a stratification of the heart failure (HF) phenotypes, which classifies HF into 3 subtypes based on ejection fraction, has been introduced. Before that, clinical trials and registries have been mainly devoted to HF with reduced ejection fraction (HFrEF). As a result, data on long‑term survival trends for individual HF phenotypes are scarce.
View Article and Find Full Text PDFMethylated arginine metabolites interrupt nitric oxide synthesis, which can result in endothelium dysfunction and inadequate vasodilation. Since little is known about the dynamics of arginine derivatives in patients with heart failure (HF) during physical exercise, we aimed to determine this as well as its impact on the patient outcomes. Fifty-one patients with HF (left ventricle ejection fraction-LVEF ≤ 35%, mean 21.
View Article and Find Full Text PDFIntroduction: There is still little information regarding a detailed description and predictors of different subtypes of heart failure (HF) in the Polish population.
Objectives: This study sought to characterize the differences between hospitalized patients with HF divided into HF with preserved ejection fraction (HFpEF; EF ≥50%), mildly reduced EF (HFmrEF; EF 40%-49%), and reduced EF (HFrEF; EF <40%), and to identify factors related to each HF subtype.
Patients And Methods: Patients from the hospital database whose hospitalization was coded as HF‑related between 2014 and 2019 were included in the analysis.
Background: The prognosis of patients with advanced heart failure is unfavourable. However, little is known about the survival of patients referred for heart transplantation but finally disqualified from transplantation due to contraindications. This study aimed to evaluate the prognosis of patients' disqualified from heart transplantation.
View Article and Find Full Text PDFBackground: Heart failure patients presenting with iron deficiency can benefit from systemic iron supplementation; however, there is the potential for iron overload to occur, which can seriously damage the heart. Therefore, myocardial iron (M-Iron) content should be precisely balanced, especially in already failing hearts. Unfortunately, the assessment of M-Iron via repeated heart biopsies or magnetic resonance imaging is unrealistic, and alternative serum markers must be found.
View Article and Find Full Text PDFWe try to determine the association between weight changes (WC), both loss or gain, body composition indices (BCI) and serum levels of 25[OH]D during heart failure (HF). WC was determined in 412 patients (14.3% female, aged: 53.
View Article and Find Full Text PDFArticle Synopsis
- Most cardiomyopathies are inherited in an autosomal dominant manner, leading to genetic testing for patients with family histories of the disease.
- The study focused on finding de novo mutations—new mutations that are not inherited—from 12 patients with cardiomyopathy and no family history of the condition.
- The researchers discovered de novo variants in cardiomyopathy-related genes in 66.7% of the cases, and they also identified new candidate genes that could influence immune responses, particularly for patients whose symptoms began after infections or infestations.
Introduction: Endothelial progenitor cells (EPCs) in nontransplant settings have reparative properties. However, their role in heart transplantation (HT) is not well defined.
Objectives: The aim of this study was to prospectively evaluate changes in EPC levels in relation to post‑HT rejection.
Background: Organizational and educational activities in primary care in Poland have been introduced to improve the chronic heart failure (CHF) management.
Objectives: To assess the use of diagnostic procedures, pharmacotherapy and referrals of CHF in primary care in Poland.
Methods: The cross-sectional survey was conducted in 2013, involving 390 primary care centres randomly selected from a national database.
Background: Optimal management of heart failure (HF) patients is crucial to reduce both mortality and the number of hospital admissions, at the same time improving patients' quality of life.
Aim: The aim of the study was to assess the quality of care of hospitalised patients with HF in Poland in 2013 and compare it with the results of a similar survey performed in 2005.
Methods: The presented study was conducted from April to November 2013 in a sample of 260 hospital wards in Poland, recruited by stratified proportional sampling.
Higher serum phosphorus is associated with catabolic/anabolic imbalance in heart failure.
J Cachexia Sarcopenia Muscle
December 2015
Background: A higher serum phosphate level is associated with worse outcome. Energy-demanding intracellular transport of phosphate is needed to secure anion bioavailability. In heart failure (HF), energy starvation may modify intracellular and serum levels of phosphate.
View Article and Find Full Text PDFIntroduction: The assessment of prognosis is crucial for the clinical management of patients with heart failure (HF).
Objectives: The aim of the study was to evaluate the usefulness of novel biomarkers for the assessment of prognosis in patients with HF, compared with a detailed assessment based on routine laboratory tests.
Patients And Methods: The study included 179 patients with HF.
Serum phosphorus abnormalities may pose a risk on the cardiovascular system. In heart failure (HF) phosphorus homeostatic mechanisms are altered and may be modified by modern HF therapy. The impact of therapy optimization on phosphorus abnormalities and related outcome remains unknown.
View Article and Find Full Text PDFBackground: The benefits of rehabilitation in heart failure (HF) patients are well established. Little is known about Nordic walking (NW) training in HF patients especially in those with cardiovascular implantable electronic devices (CIEDs).
Purpose: The purpose of this study was to assess safety, effectiveness, adherence to and acceptance of home-based telemonitored NW in HF patients, including those with CIEDs (i.
Introduction: Data regarding standardized trends in mortality from heart failure (HF) in the general population are limited.
Objectives: The aim of the study was to evaluate trends in HF mortality in Poland in the years 1980-2010.
Patients And Methods: An analysis of a database of mortality records from 1980-2010 based on National Statistics was performed.
Background: Based on the results of clinical trials, the prognosis for patients with severe heart failure (HF) has improved over the last 20 years. However, clinical trials do not reflect 'real life' due to patient selection. Thus, the aim of the POLKARD-HF registry was the analysis of survival of patients with refractory HF referred for orthotopic heart transplantation (OHT).
View Article and Find Full Text PDFBackground: Coronary artery disease (CAD) is a complex disorder accounting for the majority of cardiovascular deaths and morbidity. It is believed that genetic factors explain part of the excessive risk of major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI).
Aim: To evaluate the influence on long-term prognosis of some genetic polymorphisms affecting renin-angiotensin system, inflammatory response, beta-2 adrenergic receptor, nitric oxide and platelets activity in patients with stable CAD undergoing routine PCI.
Background: Although, correction of iron deficiency and/or anemia in heart failure (HF) with iron seems promising, little is known about myocardial iron load and homeostasis. Moreover iron supplementation indications are solely based on iron serum markers. The purpose was to assess myocardial iron (M-Iron), ferritin (M-FR), transferrin receptor (M-sTfR) in HF in relation to serum Iron markers.
View Article and Find Full Text PDFBackground: It is difficult to define the optimal management of elderly heart failure (HF) patients with complex comorbidities. Thus, comprehensive characterisation of HF patients constitutes a crucial pre-condition for the successful management of this fragile population.
Aim: To analyse the 'real life' HF patients, including the evaluation of their health conditions, management and their use of public health resources.
Background: Plasma B-type natriuretic peptide (BNP) levels are closely related to symptoms in left ventricle (LV) systolic heart failure, although marked regarding heterogeneity levels among subjects are reported.
Aims: To assess the influence of right ventricle on plasma BNP in the patients with different grades of its overload secondary to severe mitral valve stenosis (MVS).
Methods: Plasma BNP was evaluated in MVS patients (n = 27) before valve replacement and during follow-up (FUV) 401 ± 42 days after operation.