A Significance of Concomitant BRAF and TERT Mutations in Polish Patients with Papillary Thyroid Microcarcinoma: A Retrospective Cohort Study Based on 430 Cases.

The incidence of papillary thyroid cancer is increasing worldwide due to more frequent pathological detection of papillary thyroid microcarcinomas (PTMC), which are cancers measuring 1 cm or less in diameter. In rare cases, the course of PTMC can be aggressive, with an increased risk of recurrence/persistent disease. The aim of this study of Polish patients diagnosed with PTMC was to assess the impact of concomitant B-type Raf kinas-activating mutation in codon 600 of exon 15 () and telomerase reverse transcriptase () hotspot mutations on clinicopathological features, response to treatment, potential recurrence, and the final outcome.

Delayed risk stratification system in pT1aN0/Nx DTC patients treated without radioactive iodine.

Purpose: Delayed risk stratification (DRS) system by Momesso and coworkers was accepted by the American Thyroid Association as a diagnostic tool for the risk stratification of unfavorable clinical outcomes and to monitor the clinical outcomes of differentiated thyroid cancer (DTC) patients treated without radioactive iodine (RAI). The aim of this study was to evaluate the DRS system in patients with pT1aN0/Nx stage.

Methods: The study included 304 low-risk patients after thyroidectomy ( = 202) or lobectomy ( = 102) without RAI and were treated at a single center.

Flavonoids from Jovibarba globifera (Crassulaceae) rosette leaves and their antioxidant activity.

Seven flavonoids new for the genus Jovibarba, kaempferol 1, kaempferol 3-O-galactopyranosyl-(1 → 2)-O-α-L-rhamnopyranoside 2, kaempferol 3-O-β-D-glucoside 3, kaempferol 3-O-α-L-rhamnopyranosyl-7-O-α-D-glucofuranosyl-(1 → 2)-O-α-L-rhamnopyranoside 4, kaempferol 3-O-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside 5, kaempferol 3,7,4'-O-trimethyl ether 6 and quercetin 7, were isolated from fresh and dried leaves of J.ovibarba globifera subsp. globifera.