Aligning corporate social responsibility with artificial intelligence in healthcare in the context of the post-COVID-19 recovery: a viewpoint.

Purpose: This study explores how corporate social responsibility (CSR) and artificial intelligence (AI) can be combined in the healthcare industry during the post-COVID-19 recovery phase. The aim is to showcase how this fusion can help tackle healthcare inequalities, enhance accessibility and support long-term sustainability.

Design/methodology/approach: Adopting a viewpoint approach, the study leverages existing literature and case studies to analyze the intersection of CSR and AI.

Legacy of Boson Clouds on Black Hole Binaries.

Superradiant clouds of ultralight bosons can leave an imprint on the gravitational waveform of black hole binaries through "ionization" and "resonances." We study the sequence of resonances as the binary evolves and show that there are only two possible outcomes, each with a distinct imprint on the waveform. If the cloud and the binary are nearly counterrotating, then the cloud survives in its original state until it enters the sensitivity band of future gravitational wave detectors, such as the Laser Interferometer Space Antenna.

BIOLOGICAL ANTIARRHYTHMICS-SODIUM CHANNEL INTERACTING PROTEINS.

Voltage gated Na channels (Na) are essential for excitation of tissues. Mutations in Nas cause a spectrum of human disease from autism and epilepsy to cardiac arrhythmias to skeletal myotonias. The carboxyl termini (CT) of Na channels are hotspots for disease-causing mutations and are richly invested with protein interaction sites.

Risk of Arrhythmic Death in Patients With Nonischemic Cardiomyopathy: JACC Review Topic of the Week.

Nonischemic cardiomyopathy (NICM) is common and patients are at significant risk for early mortality secondary to ventricular arrhythmias. Current guidelines recommend implantable cardioverter-defibrillator (ICD) therapy to decrease sudden cardiac death (SCD) in patients with heart failure and reduced left ventricular ejection fraction. However, in randomized clinical trials comprised solely of patients with NICM, primary prevention ICDs did not confer significant mortality benefit.

PROTOCOL: Do hospital leadership styles predict patient safety indicators? A systematic review.

This is the protocol for a Campbell systematic review. The objectives are as follows: The main aim of this systematic review is to identify whether hospital leadership styles predict patient safety as measured through several indicators over time. The second aim is to assess the extent to which the prediction of hospital leadership styles on patient safety indicators varies as a function of the leader's hierarchy level in the organization.

Salivary microRNA profiling dysregulation in autism spectrum disorder: A pilot study.

Introduction: Autism spectrum disorders (ASD) are the most prevalent neurobiological disorders in children. The etiology comprises genetic, epigenetic, and environmental factors such as dysfunction of the immune system. Epigenetic mechanisms are mainly represented by DNA methylation, histone modifications, and microRNAs (miRNA).

The Association of Clustered Ventricular Arrhythmia and Cycle Length With Scar Burden in Cardiomyopathy.

Background: Patients with ≥2 ventricular arrhythmia (VA) events within 3 months (clustered VA) have increased risk for mortality.

Objectives: The aim of this study was to examine the association of risk factors including scar characteristics on cardiovascular magnetic resonance imaging with clustered VA and VA cycle length in nonischemic cardiomyopathy (NICM) and ischemic cardiomyopathy (ICM).

Methods: Data from 329 primary prevention implantable cardioverter-defibrillator recipients (mean age 57 years, 26% women) were analyzed from the Left Ventricular Structural Predictors of Sudden Cardiac Death study.

Priority setting and cross-country learning: the relevance of TO-REACH for primary care.

Aim: To inform the primary care community about priorities for research in primary care as came up from the European project TO-REACH and to discuss transferability of service and policy innovations between countries.

Background: TO-REACH stands for ransfer of rganizational innovations for esilient, ffective, equitable, ccessible, sustainable and omprehensive ealth services and systems. This EU-funded project has put health systems and services research higher on the European agenda and has led to the current development of a European 'Partnership Transforming Health and Care Systems'.

Sharp Signals of Boson Clouds in Black Hole Binary Inspirals.

Gravitational waves (GWs) are an exciting new probe of physics beyond the standard models of gravity and particle physics. One interesting possibility is provided by the so-called "gravitational atom," wherein a superradiant instability spontaneously forms a cloud of ultralight bosons around a rotating black hole. The presence of these boson clouds affects the dynamics of black hole binary inspirals and their associated GW signals.

Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current.

Voltage-gated sodium (Nav1.5) channels support the genesis and brisk spatial propagation of action potentials in the heart. Disruption of Na1.

Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure.

BACKGROUNDSudden cardiac death (SCD) remains a worldwide public health problem in need of better noninvasive predictive tools. Current guidelines for primary preventive SCD therapies, such as implantable cardioverter defibrillators (ICDs), are based on left ventricular ejection fraction (LVEF), but these guidelines are imprecise: fewer than 5% of ICDs deliver lifesaving therapy per year. Impaired cardiac metabolism and ATP depletion cause arrhythmias in experimental models, but to our knowledge a link between arrhythmias and cardiac energetic abnormalities in people has not been explored, nor has the potential for metabolically predicting clinical SCD risk.

Development of high-affinity nanobodies specific for Na1.4 and Na1.5 voltage-gated sodium channel isoforms.

Voltage-gated sodium channels, Nas, are responsible for the rapid rise of action potentials in excitable tissues. Na channel mutations have been implicated in several human genetic diseases, such as hypokalemic periodic paralysis, myotonia, and long-QT and Brugada syndromes. Here, we generated high-affinity anti-Na nanobodies (Nbs), Nb17 and Nb82, that recognize the Na1.

The Journal of Clinical Investigation in the time of COVID-19.

In this editorial, we describe the experience of the JCI editors during the COVID-19 pandemic. Our goal is to share how we operated during the pandemic, recount how the JCI contributed to the response, highlight some of the major papers we published on SARS-CoV-2 and COVID-19, and impart our insights in the hope that these are helpful to journal editors that may need to deal with similar types of crises in the future.

Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC.

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive heart condition which causes fibro-fatty myocardial scarring, ventricular arrhythmias, and sudden cardiac death. Most cases of ARVC can be linked to pathogenic mutations in the cardiac desmosome, but the pathophysiology is not well understood, particularly in early phases when arrhythmias can develop prior to structural changes. Here, we created a novel human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) model of ARVC from a patient with a c.

Unregulated online sales of cardiac implantable electronic devices in the United States: A six-month assessment.

Background: An estimated 1 million patients require cardiac implantable electronic devices (CIEDs) but go without annually. This disparity exists in low-to-middle-income nations largely owing to the cost of CIED hardware. of CIEDs has been shown to be safe and feasible.

SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes.

Brown adipose tissue (BAT) activity plays a key role in regulating systemic energy. The activation of BAT results in increased energy expenditure, making this tissue an attractive pharmacological target for therapies against obesity and type 2 diabetes. Sirtuin 5 (SIRT5) affects BAT function by regulating adipogenic transcription factor expression and mitochondrial respiration.

Elementary mechanisms of calmodulin regulation of Na1.5 producing divergent arrhythmogenic phenotypes.

In cardiomyocytes, Na1.5 channels mediate initiation and fast propagation of action potentials. The Ca-binding protein calmodulin (CaM) serves as a de facto subunit of Na1.