Predictive Significance of Combined Plasmatic Detection of BRAF Mutations and S100B Tumor Marker in Early-Stage Malignant Melanoma.

Background: Melanoma is the most aggressive skin cancer with ability to recur also after early-stage tumor surgery. The aim was to identify early-stage melanoma patients at high risk of recurrence using liquid biopsy, estimating of mutated BRAF ctDNA and the level of tumor marker S100B in plasma.

Methods: Eighty patients were enrolled in the study.

Preoperative Plasma miRNA Levels Predict Prognosis in Early-stage Malignant Melanoma.

Background/aim: Non-invasive circulating tumor biomarkers in liquid biopsy, such as microRNAs (miRNA), provide for better personalization of treatment strategies. The aim of our study was to assess the prognosis of patients with melanoma undergoing tumor resection with curative intent based on analysis of selected circulating miRNAs.

Patients And Methods: A total of 22 patients with stage I to III melanoma were enrolled into this prospective study.

Rapid growth and slow involution of Reed nevus in a long-term dermoscopic follow-up.

We describe the rapid growth of a Reed nevus followed by its slow involution and present dermoscopic follow-up images. The child was monitored for 10 years (from age 3 to 13 years) by digital dermoscopy. The Reed nevus completely lost its typical dermoscopic arrangement (starburst pattern) with involution and distinct changes in dermoscopic pattern.

Clinical-Dermoscopic-Histopathological Correlations in Collision Skin Tumours.

Objectives: Collision tumours are rare situations characterised by the coincidence of two different skin neoplasms in the same lesion.

Methods: We have analyzed 41 collision skin tumours from one department in the clinical-dermoscopic-histopathologic correlations.

Results: We present 41 collisions tumours.

The use of 2940-nm ER:YAG laser for the treatment of lentigo maligna.

Objectives: Lentigo maligna is a common in situ malignancy in elderly patients, with a low risk of progression to an invasive tumor. Surgical treatment may be complicated or refused. Non-surgical treatment options (such as lasers) may therefore be needed.

Pigmented squamous intraepithelial neoplasia of the anogenital area: a histopathological and immunohistochemical study of 64 specimens from 45 patients exploring the mechanisms of pigmentation.

Pigmented lesions in the anogenital area encompass a wide variety of disorders including squamous intraepithelial neoplasia. The authors sought to explore the mechanism(s) underlying clinically pigmented squamous intraepithelial neoplasia in the anogenital area. A light-microscopic and immunohistochemical study of 64 lesional specimens from 45 patients (32 women, 13 men; age range, 23-73 years) with pigmented lesions in the anogenital area was performed.

Dermatoscopic differences between atypical melanocytic naevi and thin malignant melanomas.

Dermatoscopy is used to aid in the differential diagnosis of pigmented skin lesions. The aim of this study was to identify dermatoscopic differences between atypical melanocytic naevi and thin malignant melanomas. A set of 180 difficult cases (60 thin melanomas, 120 clinically atypical benign melanocytic naevi) was analysed.

Cryosurgery in the treatment of earlobe keloids: report of seven cases.

Background: Keloids are benign cutaneous lesions that result from excessive collagen synthesis and deposition. Earlobe keloids in particular are seen as a complication of plastic surgery or piercing. Many different treatment modalities have been used, often with unsatisfactory results.

[The use of the 308 nm excimer laser for the treatment of psoriasis].

Background And Objective: Standard phototherapy for psoriasis (311 nm UVB or photochemotherapy) exposes the non-affected skin to potentially damaging irradiation. The use of 308 nm XeCl excimer laser allows the selective irradiation of psoriatic lesions. We evaluated its therapeutic effectiveness.