Arbitrary-Region Raster Image Correlation Spectroscopy.

Combining imaging with correlation spectroscopy, as in raster image correlation spectroscopy (RICS), makes it possible to extract molecular translational diffusion constants and absolute concentrations, and determine intermolecular interactions from single-channel or multicolor confocal laser-scanning microscopy (CLSM) images. Region-specific RICS analysis remains very challenging because correlations are always calculated in a square region-of-interest (ROI). In this study, we describe a generalized image correlation spectroscopy algorithm that accepts arbitrarily shaped ROIs.

The effect of intensive speech rate and intonation therapy on intelligibility in Parkinson's disease.

Purpose: Most studies on treatment of prosody in individuals with dysarthria due to Parkinson's disease are based on intensive treatment of loudness. The present study investigates the effect of intensive treatment of speech rate and intonation on the intelligibility of individuals with dysarthria due to Parkinson's disease.

Methods: A one group pretest-posttest design was used to compare intelligibility, speech rate, and intonation before and after treatment.

Automated Speech Rate Measurement in Dysarthria.

Purpose: In this study, a new algorithm for automated determination of speech rate (SR) in dysarthric speech is evaluated. We investigated how reliably the algorithm calculates the SR of dysarthric speech samples when compared with calculation performed by speech-language pathologists.

Method: The new algorithm was trained and tested using Dutch speech samples of 36 speakers with no history of speech impairment and 40 speakers with mild to moderate dysarthria.