Publications by authors named "Tom Waterfield"
Article Synopsis
- Differentiating between bacterial and viral infections in children is important for proper treatment, and new immune biomarkers may help identify those needing antibiotics.
- This study measured levels of three biomarkers (IP-10, LCN2, TRAIL) in healthy children aged 2 to 16 years across the UK, establishing reference intervals for their levels.
- The research found that while no biomarker was linked to sex and IP-10 showed no age correlation, LCN2 levels increased with age and TRAIL had a weak negative correlation, suggesting these biomarkers could enhance pediatric infection diagnosis and better inform clinical decisions.
Article Synopsis
- Young febrile infants are at increased risk of invasive bacterial infections, necessitating careful initial assessments that may involve blood biomarkers like C reactive protein (CRP) and procalcitonin (PCT), although PCT is not commonly used in the UK.
- The objective of the review is to evaluate the diagnostic accuracy of PCT in identifying invasive bacterial infections in infants under 91 days and compare its performance with CRP while determining the best PCT cut-off values.
- The study will systematically search various databases for relevant diagnostic accuracy studies, assess their quality, and present the findings in peer-reviewed journals and conferences, with completion aimed for 2023.
Background: A novel coronavirus SARS-CoV-2 has been responsible for a worldwide pandemic. Children typically have very mild, or no, symptoms of infection. This makes estimations of seroprevalence in children difficult.
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