Synopsis of recent research by authors named "Tom Van De Casteele"
- Tom Van de Casteele's recent research primarily focuses on innovative approaches in clinical trials, particularly decentralized clinical trials (DCTs) in Neuroscience, exploring their potential to enhance patient-centricity while addressing statistical challenges associated with such methodologies.
- In the realm of neuropeptides and headache disorders, he investigated the effects of the monoclonal antibody Lu AG09222 on PACAP38 and VIP-induced vasodilation and headache in healthy subjects, contributing to understanding migraine pathophysiology.
- His work also addresses the reproducibility and internal validity of preclinical research, advocating for improved methodologies that consider biological variation and integrate systematic guidelines to enhance the quality and transparency of studies involving laboratory animals.
