Molecular data show conserved DNA locations distinguishing lung cancer subtypes and regulation of immune genes.

Introduction: Non-small-cell lung cancer exhibits a range of transcriptional and epigenetic patterns that not only define distinct phenotypes, but may also govern immune related genes, which have a major impact on survival.

Methods: We used open-source RNA expression and DNA methylation data of the Cancer Genome Atlas with matched non-cancerous tissue to evaluate whether these pretreatment molecular patterns also influenced genes related to the immune system and overall survival.

Results: The distinction between lung adenocarcinoma and squamous cell carcinoma are determined by 1083 conserved methylation loci and RNA expression of 203 genes which differ for >80 % of patients between the two subtypes.

Interview with Tom Peters. Father of post-modern corporation speaks out. Interview by Richard D. Brennan, Jr.

Tom Peters has been selected as the opening Keynote speaker at the National Association for Home Care and Hospice's Annual Meeting in Seattle, Washington on October 23-26, 2005. Peters has been described by the Los Angeles Times as the "father of the post-modern corporation." The New Yorker said, "In no small part, what American corporations have become is what Peters has encouraged them to be.

Performance reassessment of a real-time seizure-detection algorithm on long ECoG series.

Purpose: Automated seizure detection and blockage requires highly sensitive and specific algorithms. This study reassessed the performance of an algorithm by using a more extensive database than that of a previous study and its suitability for safety/efficacy closed-loop studies to block seizures in humans.

Methods: Up to eight electrocorticography (EcoG) channels from 15 subjects were analyzed off-line.