Overhauser Dynamic Nuclear Polarization Enables Single Scan Benchtop C NMR Spectroscopy in Continuous-Flow.

Benchtop C NMR spectroscopy is highly attractive for reaction and process monitoring. However, insufficient premagnetization and low signal intensities largely prevent its application to flowing liquids. We show that hyperpolarization by Overhauser dynamic nuclear polarization (ODNP) can be used to overcome these problems, as ODNP operates on short time scales and results in strong C signal enhancements.