Maintenance of cellular respiration indicates drug resistance in acute myeloid leukemia.

Primary resistance to induction therapy is an unsolved clinical problem in acute myeloid leukemia (AML). Here we investigated drug resistance in AML at the level of cellular metabolism in order to identify early predictors of therapeutic response. Using extracellular flux analysis, we compared metabolic drug responses in AML cell lines sensitive or resistant to cytarabine or sorafenib after 24h of drug treatment to a small cell lung cancer (SCLC) cell line exposed to etoposide.

Use of bar coding technology to flag ER patients on metformin-containing drugs.

Sixty percent of Jennie Edmundson Hospital's inpatients are admitted through the emergency room. Type II diabetes accounts for 90-95% of all diagnosed cases of diabetes. There were about 1.