Publications by authors named "Tom Gillis"
CTP synthases (CTPS) catalyze the de novo production of CTP using UTP, ATP, and l-glutamine with the anticancer drug metabolite gemcitabine-5'-triphosphate (dF-dCTP) being one of its most potent nucleotide inhibitors. To delineate the structural origins of this inhibition, we solved the structures of Escherichia coli CTPS (ecCTPS) in complex with CTP (2.0 Å), 2'-ribo-F-dCTP (2.
View Article and Find Full Text PDFTuberculosis (TB) and leprosy still represent significant public health challenges, especially in low- and lower middle-income countries. Both poverty-related mycobacterial diseases require better tools to improve disease control. For leprosy, there has been an increased emphasis on developing tools for improved detection of infection and early diagnosis of disease.
View Article and Find Full Text PDFArticle Synopsis
- A patient in Ottawa, Canada, presented with symptoms resembling leprosy due to an infection by Mycobacterium lepromatosis, despite having no travel history to areas where leprosy is common.
- Clinical examinations showed a rash and neurological issues, including severe sensorimotor polyneuropathy, further complicated by a diagnosis of lung cancer.
- The identification of M. lepromatosis was confirmed through molecular studies, and although the patient received treatment, he ultimately passed away from his cancer about five months later.
Objectives: To study the suitability, stability and diversity of short tandem repeat (STR) genomic markers to elicit strain variation in the Mycobacterium leprae isolates within leprosy patients from Andhra Pradesh and Tamil Nadu states in South India.
Materials And Methods: Slit skin smear (SSS) samples were collected from lesions and various body sites of newly diagnosed leprosy patients. The SSSs from each patient were pooled, except in the case of five patients.