Publications by authors named "Tom G Hendriks"
Bioorg Med Chem
October 2014
Article Synopsis
- To create effective biosensor platforms, specific ligands with functional handles are essential for proper immobilization on sensor surfaces.
- A library of papain inhibitors featuring various azide linkers was developed, utilizing copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) for immobilization.
- Molecular docking studies revealed that while the azide group is small, its incorporation can significantly impact binding affinity; a suitable linker position was identified to maintain affinity.
