Association between chronic acetaminophen exposure and allergic rhinitis in a rat model.

Background: Several population studies demonstrated an increased risk of allergic rhinitis in patients exposed to acetaminophen. However, no histologic studies have been conducted to assess the relationship between acetaminophen exposure and allergic rhinitis.

Objective: In this study, we investigated the association between chronic acetaminophen exposure and the development of allergic rhinitis in a rat model.